Metabolic health results from a mix of genetic, constitutional, and environmental factors (e.g., age, sex, diet) whose impact differs between the two sexes. Similarly, metabolic disorders and their associated risk factors (e.g., cardiovascular disease, type 2 diabetes, stroke, high blood pressure, obesity) differently affect men and women. Some metabolic-related disorders are peculiar only for women (e.g., polycystic ovary syndrome, gestational diabetes mellitus, and some types of sex-dependent cancers), while others show different incidence, course and outcome depending on sex (e.g., type 2 diabetes, metabolic syndrome, hypertensive disorders, neurodegenerative diseases, sarcopenia, and osteoporosis). For example obesity, which can occur in both men and women, is a negative factor for the feminine reproductive functions, impinging on the ovulation rate. Therefore, the identification of altered pathways in female subjects, as well as the design of specific therapeutic strategies, is mandatory for the development of precision medicine aimed to improve expectancy and quality of life as well as fertility in women.
The aim of this topic is to cover all the aspects of female metabolism, with particular emphasis on molecular and clinical findings about sex-specific disorders, diet-related diseases, cancers, as well as sex-related differences in cellular pathways, clinical outcome and therapy response for pathologies affecting both sexes.
We welcome the submission of Original Research articles, Reviews and Mini-Reviews related to the following themes:
- Molecular mechanisms underlying development and progression of metabolic disorders and cancers in women.
- Effects of sex and sex-hormones on the development and progression of chronic metabolic diseases and cancers, as well as therapy response.
- Molecular links between metabolism, pregnancy and infertility.
- The impact of diet, specific nutrients (macro- and micronutrients), radical scavengers (polyphenols, fruit-derived compounds, agri-food by-products) in the management of female health status and related diseases.
- Sex-specific in vivo models.
- Sex-specific biomarkers.
- New diagnostic factors in the management of women's metabolic health and fertility.
Please note, for submissions to Cancer Cell Biology: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
Metabolic health results from a mix of genetic, constitutional, and environmental factors (e.g., age, sex, diet) whose impact differs between the two sexes. Similarly, metabolic disorders and their associated risk factors (e.g., cardiovascular disease, type 2 diabetes, stroke, high blood pressure, obesity) differently affect men and women. Some metabolic-related disorders are peculiar only for women (e.g., polycystic ovary syndrome, gestational diabetes mellitus, and some types of sex-dependent cancers), while others show different incidence, course and outcome depending on sex (e.g., type 2 diabetes, metabolic syndrome, hypertensive disorders, neurodegenerative diseases, sarcopenia, and osteoporosis). For example obesity, which can occur in both men and women, is a negative factor for the feminine reproductive functions, impinging on the ovulation rate. Therefore, the identification of altered pathways in female subjects, as well as the design of specific therapeutic strategies, is mandatory for the development of precision medicine aimed to improve expectancy and quality of life as well as fertility in women.
The aim of this topic is to cover all the aspects of female metabolism, with particular emphasis on molecular and clinical findings about sex-specific disorders, diet-related diseases, cancers, as well as sex-related differences in cellular pathways, clinical outcome and therapy response for pathologies affecting both sexes.
We welcome the submission of Original Research articles, Reviews and Mini-Reviews related to the following themes:
- Molecular mechanisms underlying development and progression of metabolic disorders and cancers in women.
- Effects of sex and sex-hormones on the development and progression of chronic metabolic diseases and cancers, as well as therapy response.
- Molecular links between metabolism, pregnancy and infertility.
- The impact of diet, specific nutrients (macro- and micronutrients), radical scavengers (polyphenols, fruit-derived compounds, agri-food by-products) in the management of female health status and related diseases.
- Sex-specific in vivo models.
- Sex-specific biomarkers.
- New diagnostic factors in the management of women's metabolic health and fertility.
Please note, for submissions to Cancer Cell Biology: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
