Microbes are very important and convey substantial benefits to the human body. Gut microbes significantly regulate host metabolism by regulating microbe-mediated gut hormone release. Microbes produce various metabolites that act as message molecules for many cell types. The mucosal lining of the gut release various hormones such as peptide YY, Cholecystokinin, Gastric inhibitory polypeptide hormone, Glucagon-like peptide 1, and 5-hydroxytryptamine. These hormones strongly regulate key metabolic pathways such as glucose metabolism, fat metabolism, and insulin sensitivity and command appetite. Changes in molecular interactions among the intestinal epithelium, gut microbiota, cellular metabolism, and host immune system influence the incidence and progression of several diseases including cancer. Alteration in gut microbiota also controls inflammatory cytokines and thus regulates associated circuitries. Pharmacological phytochemicals or different diets alter the gut microbiome and therefore give clues for treating metabolic disorders.
In this Research Topic, we welcome the submission of original research articles (in vitro, animal, and human studies, as well as in silico studies), review articles, and perspectives that could stimulate the continuing efforts to better understand the role of the microbiome in alteration of cellular metabolism and development of cancer. We welcome submissions from a broad range of topics, including (but not limited to) the following: Microbes, gut microbiome, cancer, the aggressiveness of the disease, experimental therapeutics, cellular metabolism, etc.
Microbes are very important and convey substantial benefits to the human body. Gut microbes significantly regulate host metabolism by regulating microbe-mediated gut hormone release. Microbes produce various metabolites that act as message molecules for many cell types. The mucosal lining of the gut release various hormones such as peptide YY, Cholecystokinin, Gastric inhibitory polypeptide hormone, Glucagon-like peptide 1, and 5-hydroxytryptamine. These hormones strongly regulate key metabolic pathways such as glucose metabolism, fat metabolism, and insulin sensitivity and command appetite. Changes in molecular interactions among the intestinal epithelium, gut microbiota, cellular metabolism, and host immune system influence the incidence and progression of several diseases including cancer. Alteration in gut microbiota also controls inflammatory cytokines and thus regulates associated circuitries. Pharmacological phytochemicals or different diets alter the gut microbiome and therefore give clues for treating metabolic disorders.
In this Research Topic, we welcome the submission of original research articles (in vitro, animal, and human studies, as well as in silico studies), review articles, and perspectives that could stimulate the continuing efforts to better understand the role of the microbiome in alteration of cellular metabolism and development of cancer. We welcome submissions from a broad range of topics, including (but not limited to) the following: Microbes, gut microbiome, cancer, the aggressiveness of the disease, experimental therapeutics, cellular metabolism, etc.