More and more studies have demonstrated that the tumor microenvironment (TME) plays a vital role in the tumor progression and tumor metastasis. The components of TME are very complicated, including cellular components (e.g., cancer cells, immune cells, endothelial cells, fibroblasts, mast cells) and non-cellular components (e.g., extracellular matrix, cytokines, chemokines, signal molecules). The interactions between those components can determine the trend of tumor progression, which can be divided into anti-tumor and pro-tumor.
In order to identify the potential biomarkers and targets for the cancer therapy, it is necessary to pay more attention in TME, especially the interaction between different components in TME. Due to the complexity of TME, the functions and the underlying mechanisms of the TME components in cancer poor prognosis and cancer metastasis is not completely understood. The purpose of this research topic is to better characterize the components in the TME and to investigate their roles during the progression and metastasis of different cancer types.
To identify and characterize novel cellular and non-cellular components in TME involved in the cancer progression and metastasis, we welcome research articles and reviews that include, but are not limited to, the following topics,
• The interactions between tumor cells and immune cells in cancer development
• Inflammatory cytokines and chemokines in the tumor progression
• The crosstalk between different cells within the TME
• Extracellular matrix as new targets for the tumor therapy
• The metabolism-related factors in the TME
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
More and more studies have demonstrated that the tumor microenvironment (TME) plays a vital role in the tumor progression and tumor metastasis. The components of TME are very complicated, including cellular components (e.g., cancer cells, immune cells, endothelial cells, fibroblasts, mast cells) and non-cellular components (e.g., extracellular matrix, cytokines, chemokines, signal molecules). The interactions between those components can determine the trend of tumor progression, which can be divided into anti-tumor and pro-tumor.
In order to identify the potential biomarkers and targets for the cancer therapy, it is necessary to pay more attention in TME, especially the interaction between different components in TME. Due to the complexity of TME, the functions and the underlying mechanisms of the TME components in cancer poor prognosis and cancer metastasis is not completely understood. The purpose of this research topic is to better characterize the components in the TME and to investigate their roles during the progression and metastasis of different cancer types.
To identify and characterize novel cellular and non-cellular components in TME involved in the cancer progression and metastasis, we welcome research articles and reviews that include, but are not limited to, the following topics,
• The interactions between tumor cells and immune cells in cancer development
• Inflammatory cytokines and chemokines in the tumor progression
• The crosstalk between different cells within the TME
• Extracellular matrix as new targets for the tumor therapy
• The metabolism-related factors in the TME
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
