Microbes take part in various physiological metabolic processes of our bodies, involving digestion, nutrition, metabolism, and immunity, which are closely related to the occurrence and development of various intestinal and extra-intestinal diseases. Recent studies have witnessed the dramatic developments of bacteria and their derivatives mediated biotherapies and biotic/abiotic hybrid therapies. However, surface-associated immunogenicity and dose-dependent virulence and limited efficacy restrict the further development and clinical translation of bacteria-based therapies. To tackle the above issues, various surface decoration strategies derived from physical, chemical, and biological means have been proposed for microbes and their derivatives, which realize the high-efficient combination between bacteria and diverse materials, such as contrast agents, anticancer drugs, nanoparticles and polymers. These organic/inorganic or biotic/abiotic hybrid systems circumvent the inadequacies and amplify the advantages of bacteria-based biotherapies, which will gain satisfactory outcomes in the diagnosis and treatment of diseases.
The aim of this Research Topic is to provide comprehensive coverage of the relevant topics concerning the new strategies and materials of microbe decoration for the diagnosis and treatment of diseases. Special emphasis will be given to studies that create new strategies for decoration of microbe or provide insight into the therapeutic mechanisms of the decorated bacteria.
The scope of this Research Topic covers but is not limited to:
- Novel strategies to coat or link drug or functional materials on the surface of microbe, such as polymerization, self-assembly, electronic bonding, mineralization, layer-by-layer coating, etc.
- Potential materials can be used to decorate microbe (Biomaterials, synthetic materials, cell-based materials, etc).
- Microbe and its derivatives used for disease treatment and bioimage and diagnosis.
- Novel drug or functional nanomaterials was delivered by microbe for synergistic cancer therapy, immunoregulation, gut microbiota balance.
- Development of decoration methods for improving oral administrator effectiveness, intestinal colonization ability, immune escape, tumor targeting, etc.
Microbes take part in various physiological metabolic processes of our bodies, involving digestion, nutrition, metabolism, and immunity, which are closely related to the occurrence and development of various intestinal and extra-intestinal diseases. Recent studies have witnessed the dramatic developments of bacteria and their derivatives mediated biotherapies and biotic/abiotic hybrid therapies. However, surface-associated immunogenicity and dose-dependent virulence and limited efficacy restrict the further development and clinical translation of bacteria-based therapies. To tackle the above issues, various surface decoration strategies derived from physical, chemical, and biological means have been proposed for microbes and their derivatives, which realize the high-efficient combination between bacteria and diverse materials, such as contrast agents, anticancer drugs, nanoparticles and polymers. These organic/inorganic or biotic/abiotic hybrid systems circumvent the inadequacies and amplify the advantages of bacteria-based biotherapies, which will gain satisfactory outcomes in the diagnosis and treatment of diseases.
The aim of this Research Topic is to provide comprehensive coverage of the relevant topics concerning the new strategies and materials of microbe decoration for the diagnosis and treatment of diseases. Special emphasis will be given to studies that create new strategies for decoration of microbe or provide insight into the therapeutic mechanisms of the decorated bacteria.
The scope of this Research Topic covers but is not limited to:
- Novel strategies to coat or link drug or functional materials on the surface of microbe, such as polymerization, self-assembly, electronic bonding, mineralization, layer-by-layer coating, etc.
- Potential materials can be used to decorate microbe (Biomaterials, synthetic materials, cell-based materials, etc).
- Microbe and its derivatives used for disease treatment and bioimage and diagnosis.
- Novel drug or functional nanomaterials was delivered by microbe for synergistic cancer therapy, immunoregulation, gut microbiota balance.
- Development of decoration methods for improving oral administrator effectiveness, intestinal colonization ability, immune escape, tumor targeting, etc.
