Dental tissues are rich and accessible sources of mesenchymal stem cells such as dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), dental follicle cells (DFCs), stem cells from human exfoliated deciduous teeth (SHED), and stem cells from apical papilla (SCAP) that offer attractive opportunities for regenerative therapies. Recruitment of endogenous stem cells or introduction of in-vitro expanded stem cells in a tissue engineering strategy are the two principal techniques in regenerative dentistry. The regenerative process however is complex and is orchestrated by a variety of molecular mediators and pathways that may differ significantly from native tissue development. Currently, exploring and increasing our knowledge of these mechanisms is a key priority in dental research, which will assist in identifying key targets for the development of future dental regenerative strategies.
Unraveling these fundamental mechanisms will not only help in improving current methods to a higher standard of safety and efficacy but also offers potential novel therapeutic targets in regenerative dentistry. Therefore, this Research Topic aims to enhance the understanding of a range of molecular mediators that promote or control dental regeneration to highlight new avenues and challenges, as well as potential new therapeutic strategies in vital pulp treatment and regenerative dentistry.
Original research, reviews, methods, and perspectives on the following and other related subjects are welcomed:
• Molecular mechanisms involved in any processes of dental generation/regeneration (i.e. stem cell proliferation, differentiation, inflammation control, mineralisation, angiogenesis)
• Molecular mechanisms controlling dental stem cells
• Chemical approaches for dental regeneration
• Current dental regenerative therapies and their limitations, and perspective for the future
• Translational studies from cellular to tissue engineering in dentistry
Dental tissues are rich and accessible sources of mesenchymal stem cells such as dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), dental follicle cells (DFCs), stem cells from human exfoliated deciduous teeth (SHED), and stem cells from apical papilla (SCAP) that offer attractive opportunities for regenerative therapies. Recruitment of endogenous stem cells or introduction of in-vitro expanded stem cells in a tissue engineering strategy are the two principal techniques in regenerative dentistry. The regenerative process however is complex and is orchestrated by a variety of molecular mediators and pathways that may differ significantly from native tissue development. Currently, exploring and increasing our knowledge of these mechanisms is a key priority in dental research, which will assist in identifying key targets for the development of future dental regenerative strategies.
Unraveling these fundamental mechanisms will not only help in improving current methods to a higher standard of safety and efficacy but also offers potential novel therapeutic targets in regenerative dentistry. Therefore, this Research Topic aims to enhance the understanding of a range of molecular mediators that promote or control dental regeneration to highlight new avenues and challenges, as well as potential new therapeutic strategies in vital pulp treatment and regenerative dentistry.
Original research, reviews, methods, and perspectives on the following and other related subjects are welcomed:
• Molecular mechanisms involved in any processes of dental generation/regeneration (i.e. stem cell proliferation, differentiation, inflammation control, mineralisation, angiogenesis)
• Molecular mechanisms controlling dental stem cells
• Chemical approaches for dental regeneration
• Current dental regenerative therapies and their limitations, and perspective for the future
• Translational studies from cellular to tissue engineering in dentistry
