The prevalence of overweight or obesity has been increasing in recent years, especially during the COVID-19 pandemic. Regional policies enforced on social distancing, school closures, and online courses resulting in less daily physical activity have increased the incidence of overweight and obesity, further mediated the incidence of precocious puberty. Overweight or obesity is positively associated with early puberty in girls, but the relationship is controversial in boys. Furthermore, the mechanism of obesity-mediated puberty development is largely unknown.
In addition, the timing of puberty is influenced by a complex interplay of genetic and environmental factors, especially the widespread presence of environmental endocrine disruptors (EED). Increasing pieces of literature reported the association between genetics and precocious puberty, however, data on the effect of EED on early puberty are limited. Collectively, these factors are contributing to early susceptibility of insulin resistance and type 2 diabetes.
This Research Topic is dedicated to exploring the most recent advances in the effect of overweight or obesity on early puberty (or precocious puberty) and their associated metabolic disease risk factors. In addition, we encourage researchers to study genetic or environmental risk factors of precocious puberty; as well as the impact on chronic disease development.
We welcome Original Research, Reviews, Mini reviews, and Perspective articles related to the following subjects, including but not limited to:
• Association of overweight or obesity with precocious puberty in COVID-19;
• Genetic variation of obesity or BMI with early puberty;
• Environmental factors such as EED that can cause early puberty or precocious puberty;
• Association of lifestyle (i.e., sleep, physical activity, diet, or screen exposure) with obesity and puberty;
• Metabolic complications of pediatric obesity: dyslipidemia, glucose and insulin regulation, insulin resistance, CVD risk, early biomarkers and interventions.
The prevalence of overweight or obesity has been increasing in recent years, especially during the COVID-19 pandemic. Regional policies enforced on social distancing, school closures, and online courses resulting in less daily physical activity have increased the incidence of overweight and obesity, further mediated the incidence of precocious puberty. Overweight or obesity is positively associated with early puberty in girls, but the relationship is controversial in boys. Furthermore, the mechanism of obesity-mediated puberty development is largely unknown.
In addition, the timing of puberty is influenced by a complex interplay of genetic and environmental factors, especially the widespread presence of environmental endocrine disruptors (EED). Increasing pieces of literature reported the association between genetics and precocious puberty, however, data on the effect of EED on early puberty are limited. Collectively, these factors are contributing to early susceptibility of insulin resistance and type 2 diabetes.
This Research Topic is dedicated to exploring the most recent advances in the effect of overweight or obesity on early puberty (or precocious puberty) and their associated metabolic disease risk factors. In addition, we encourage researchers to study genetic or environmental risk factors of precocious puberty; as well as the impact on chronic disease development.
We welcome Original Research, Reviews, Mini reviews, and Perspective articles related to the following subjects, including but not limited to:
• Association of overweight or obesity with precocious puberty in COVID-19;
• Genetic variation of obesity or BMI with early puberty;
• Environmental factors such as EED that can cause early puberty or precocious puberty;
• Association of lifestyle (i.e., sleep, physical activity, diet, or screen exposure) with obesity and puberty;
• Metabolic complications of pediatric obesity: dyslipidemia, glucose and insulin regulation, insulin resistance, CVD risk, early biomarkers and interventions.
