About this Research Topic
Over the past decade, several proteins have been proposed as possible biomarkers of synaptic damage, and the most studied synaptic proteins are neurogranin, synaptosome-associated protein 25 (SNAP-25), synaptotagmin-1, and growth-associated protein 43 (GAP-43). Other synaptic proteins are emerging. Finally, a PET tracer binding vesicular synaptic glycoprotein 2A (SV2) has recently been developed, which can be used to quantify synaptic density in vivo. However, there is currently no consensus on the use of these synaptic biomarkers and thus further studies are needed.
Our Research Topic aims to raise the research discussion on the relevance of synaptic biomarkers in Alzheimer’s disease and related dementias and improve our understanding of the early pathophysiological events involved in these diseases. We wish to spotlight the most recent discoveries from the preclinical and clinical research regarding the identification of synaptic biomarkers which may ultimately contribute to solving the current need for biomarkers with diagnostic and prognostic value for Alzheimer’s disease and related dementias.
We welcome any type of manuscript supported by the journal, including original research articles, brief research articles, case reports, reviews, mini-reviews, and meta-analyses, concerning, but not limited to:
- the study of the pathophysiology of synaptic disruption in Alzheimer's disease and related dementias
- preclinical models of Alzheimer's disease investigating synaptic dysfunction
- clinical studies aimed at defining the role of synaptic biomarkers in Alzheimer's disease and related dementias
- clinical studies aiming to identify novel synaptic biomarkers on cerebrospinal fluid
- clinical studies aiming to identify novel synaptic biomarkers in blood
Keywords: Synaptic biomarkers, dementia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.