About this Research Topic
This Research Topic is part of the 15 Year Anniversary of Cellular Neuroscience Research Topic series, which has been organized in collaboration with the Neuroscience portfolio at Frontiers to celebrate the 15 Year Anniversary of the journal by highlighting some of the most impactful research areas in this field and providing discussion around the latest advances in Blood Brain Barrier research as well as new research on this important topic.
By following its mission to freely disseminate high-quality research with a worldwide reach, Frontiers in Non-neuronal cells will continue to play a key role in accelerating the progress of Cellular Neuroscience research and making Open Science a global reality.
This Research Topic article collection focuses on the Blood Brain Barrier and Brain Diseases.
The Research Topic welcomes contributions from researchers around the globe in the form of Original Research, Review, Mini Review, and Perspectives focusing on, but not limited to the following subtopics:
• The understanding of the molecular pathways involved in Blood Brain Barrier (BBB) development and also BBB breakdown in neurological diseases.
• Specifically, the Wnt/β-catenin, retinoic acid and sonic hedgehog pathways and angiopoietin/Tie2 signalling that is linked to angiogenic processes.
• The potential influence of CNS blood vessels in neurological diseases associated with BBB alterations or neuroinflammation.
• Investigating how the BBB remains an obstacle to pharmaceutical intervention in the CNS, such as in brain tumours or by poor delivery of the drug across the BBB.
• The cellular and molecular components that allow for the steady state of the healthy BBB.
• Examining BBB alterations in ischaemic stroke, primary and metastatic brain tumour, chronic inflammation and Alzheimer’s disease.
• Highlighting common mechanisms of BBB abnormalities among these diseases, in particular the contribution of neuroinflammation to BBB dysfunction and disease progression,
• Investigating under-researched aspects of BBB alteration in certain diseases such as brain tumours.
• Evaluating novel strategies to monitor BBB function by non-invasive imaging techniques and ways to modulate BBB permeability and function to promote the treatment of brain tumours, inflammation and Alzheimer’s disease.
• Identify potential targets for diagnostics and therapeutic modulation of the BBB.
By following its mission to freely disseminate high-quality research with a worldwide reach, Frontiers in Non-neuronal cells will continue to play a key role in accelerating the progress of Cellular Neuroscience research and making Open Science a global reality.
This Research Topic article collection focuses on the Blood Brain Barrier and Brain Diseases.
The Research Topic welcomes contributions from researchers around the globe in the form of Original Research, Review, Mini Review, and Perspectives focusing on, but not limited to the following subtopics:
• The understanding of the molecular pathways involved in Blood Brain Barrier (BBB) development and also BBB breakdown in neurological diseases.
• Specifically, the Wnt/β-catenin, retinoic acid and sonic hedgehog pathways and angiopoietin/Tie2 signalling that is linked to angiogenic processes.
• The potential influence of CNS blood vessels in neurological diseases associated with BBB alterations or neuroinflammation.
• Investigating how the BBB remains an obstacle to pharmaceutical intervention in the CNS, such as in brain tumours or by poor delivery of the drug across the BBB.
• The cellular and molecular components that allow for the steady state of the healthy BBB.
• Examining BBB alterations in ischaemic stroke, primary and metastatic brain tumour, chronic inflammation and Alzheimer’s disease.
• Highlighting common mechanisms of BBB abnormalities among these diseases, in particular the contribution of neuroinflammation to BBB dysfunction and disease progression,
• Investigating under-researched aspects of BBB alteration in certain diseases such as brain tumours.
• Evaluating novel strategies to monitor BBB function by non-invasive imaging techniques and ways to modulate BBB permeability and function to promote the treatment of brain tumours, inflammation and Alzheimer’s disease.
• Identify potential targets for diagnostics and therapeutic modulation of the BBB.
Keywords: Blood Brain Barrier, Brain Disease, BBB, 15th Anniversary
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
