Vitamin D: From Pathophysiology to Clinical Impact

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Editorial

13 March 2025

Editorial: Vitamin D: from pathophysiology to clinical impact

Cristina Vassalle

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Editors

3

Cristina Vassalle

Gabriele Monasterio Tuscany Foundation (CNR)

Francesca Gorini

National Research Council (CNR)

Luigi Di Filippo

San Raffaele Hospital (IRCCS)

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Besides the well-known positive effects on skeletal homeostasis and bone metabolism, the growing evidence highlights the importance of vitamin D also in other many extra-skeletal conditions. In both adult and pediatric populations, conditions from inflammation and infectious diseases, obesity, and diabetes, to neurological disorders, gastrointestinal conditions, neurological disorders, cardiovascular health, and malignancies can be exerted through a number of mechanisms between vitamin D and its widely expressed receptor.

This fact contributes to the increasing attention towards 25(OH)D measurement in laboratory medicine in both healthy and non-healthy general populations. Moreover, available dosing recommendations for vitamin D supplementation may considerably vary in the literature depending on the clinical setting and specific cohort evaluated. Indeed, currently, there are no specific guidelines and no clear consensus on goals for optimal vitamin D status and supplementation in most extra-skeletal conditions.

Thus, we invite researchers to submit articles/reviews on:
• Metabolism and mechanisms of action of vitamin D
• Methods to measure vitamin D and define optimal vitamin D status in different conditions
• Effect of vitamin D supplementation
• Contribution of vitamin D to assess the risk of disease, diagnosis, and patient management in different extra-skeletal conditions

Besides the well-known positive effects on skeletal homeostasis and bone metabolism, the growing evidence highlights the importance of vitamin D also in other many extra-skeletal conditions. In both adult and pediatric populations, conditions from inflammation and infectious diseases, obesity, and diabetes, to neurological disorders, gastrointestinal conditions, neurological disorders, cardiovascular health, and malignancies can be exerted through a number of mechanisms between vitamin D and its widely expressed receptor.

This fact contributes to the increasing attention towards 25(OH)D measurement in laboratory medicine in both healthy and non-healthy general populations. Moreover, available dosing recommendations for vitamin D supplementation may considerably vary in the literature depending on the clinical setting and specific cohort evaluated. Indeed, currently, there are no specific guidelines and no clear consensus on goals for optimal vitamin D status and supplementation in most extra-skeletal conditions.

Thus, we invite researchers to submit articles/reviews on:
• Metabolism and mechanisms of action of vitamin D
• Methods to measure vitamin D and define optimal vitamin D status in different conditions
• Effect of vitamin D supplementation
• Contribution of vitamin D to assess the risk of disease, diagnosis, and patient management in different extra-skeletal conditions

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Editors

Cristina Vassalle

Gabriele Monasterio Tuscany Foundation (CNR)

Francesca Gorini

National Research Council (CNR)

Luigi Di Filippo

San Raffaele Hospital (IRCCS)

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Frontiers in Nutrition

Clinical Nutrition, Nutritional Epidemiology, Nutritional Immunology, Nutrition and Metabolism

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Frontiers in Immunology

Nutritional Immunology

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