Viral infection involves an ongoing battle between the viruses and their host, and in particular the balance between host-encoded dependency factors whose exploitation promote virus growth, and immune and inflammatory responses that control infection. In this scenario, the host innate immune response is the first line of defence against viral infections, where the direct recognition of pathogen-associated molecular patterns (PAMPs) by different pattern recognition receptors (PRRs) results in the induction of an antiviral state involving the production of interferons (IFNs) and the following upregulation of hundreds of interferon-stimulated genes (ISGs) with different antiviral properties. On the other hand, in response to these mechanisms, and to establish productive infection, many viruses have developed distinct mechanisms to escape this antiviral response by targeting different parts of the innate immune response.
Identifying the molecular mechanisms of innate immune response to viral infections is fundamental to illuminate points of viral vulnerability that may help guide the development of novel antiviral strategies. In addition, Deciphering the role and impact of all the different antiviral sensors, signaling pathways on how, where and when the innate immune system detects and responds to viral infections presents a unique opportunity to advance our knowledge about host immune response to viruses, mechanisms of innate immune evasion and the development of future therapeutic strategies against different viral diseases.
This research topic aims to attract attention to new to new advances in the understanding of the molecular mechanisms that modulate the host innate immune response against viral infections. We welcome all types of manuscripts, including reviews, original research articles, methods, short communications, case reports and opinions. The topics may include (but are not restricted to):
- Innate immune sensing of viral infection
- Viral evasion strategies of the interferon system
- Interferon-Stimulated Genes (ISGs) with antiviral activity
- The role of interferon responses in viral infections
Viral infection involves an ongoing battle between the viruses and their host, and in particular the balance between host-encoded dependency factors whose exploitation promote virus growth, and immune and inflammatory responses that control infection. In this scenario, the host innate immune response is the first line of defence against viral infections, where the direct recognition of pathogen-associated molecular patterns (PAMPs) by different pattern recognition receptors (PRRs) results in the induction of an antiviral state involving the production of interferons (IFNs) and the following upregulation of hundreds of interferon-stimulated genes (ISGs) with different antiviral properties. On the other hand, in response to these mechanisms, and to establish productive infection, many viruses have developed distinct mechanisms to escape this antiviral response by targeting different parts of the innate immune response.
Identifying the molecular mechanisms of innate immune response to viral infections is fundamental to illuminate points of viral vulnerability that may help guide the development of novel antiviral strategies. In addition, Deciphering the role and impact of all the different antiviral sensors, signaling pathways on how, where and when the innate immune system detects and responds to viral infections presents a unique opportunity to advance our knowledge about host immune response to viruses, mechanisms of innate immune evasion and the development of future therapeutic strategies against different viral diseases.
This research topic aims to attract attention to new to new advances in the understanding of the molecular mechanisms that modulate the host innate immune response against viral infections. We welcome all types of manuscripts, including reviews, original research articles, methods, short communications, case reports and opinions. The topics may include (but are not restricted to):
- Innate immune sensing of viral infection
- Viral evasion strategies of the interferon system
- Interferon-Stimulated Genes (ISGs) with antiviral activity
- The role of interferon responses in viral infections
