Steroid hormones in vertebrates comprise corticosteroid hormones (mineralocorticoids and glucocorticoids) as well as sex hormones (estrogens, androgens, progesterone). They mainly act by binding to their specific receptors (MR, GR, ER, AR, and PR, respectively) which are ligand-activated transcription factors belonging to the nuclear receptor superfamily. Over the years, beyond their functions in metabolism (glucocorticoids GR), ion homeostasis, (mineralocorticoids MR), and reproduction (ER, PR, AR), the study of the role of steroid hormones expands to the nervous system, such as in neuroprotection, neurodegenerative diseases, neurodevelopment, stress response, and behavior. Steroid hormones act on the central and peripheral nervous system and neurons as well as on glial cells. Their biological effects are mediated by the modulation of target genes after the binding to their receptors, but also by rapid non-genomic actions. Nevertheless, the different aspects of steroid biology in the nervous system are still far from well understood.
Steroid hormones influence the function of all organs in mammals. This topic aims to increase the knowledge of steroid receptor actions on the central and peripheral nervous system. It will focus on biological approaches to unravel new mechanisms of action of sex hormones and corticosteroid hormones in the nervous system such as new pathways and target genes in neurons as well as in glial cells. Particular attention will be given to papers providing new understandings and new functions of steroid receptors on pathologies linked to stress, neurodevelopment, neurodegenerative diseases, and behavior. Bringing new knowledge on steroid receptor involvement in nervous system developmental biology may be also of interest. Original articles as well as reviews synthetizing the latest knowledge on one aspect of this field of research are welcome.
The scope of this research topic is to gather articles exploring new avenues concerning:
*Steroid receptors and neurodegenerative diseases;
*Steroid receptors function in glial cells;
*Sex steroid receptor and the male and female nervous system;
*Steroid receptors in nervous system development.
It will include mainly original articles but one or two reviews will be welcome.
Steroid hormones in vertebrates comprise corticosteroid hormones (mineralocorticoids and glucocorticoids) as well as sex hormones (estrogens, androgens, progesterone). They mainly act by binding to their specific receptors (MR, GR, ER, AR, and PR, respectively) which are ligand-activated transcription factors belonging to the nuclear receptor superfamily. Over the years, beyond their functions in metabolism (glucocorticoids GR), ion homeostasis, (mineralocorticoids MR), and reproduction (ER, PR, AR), the study of the role of steroid hormones expands to the nervous system, such as in neuroprotection, neurodegenerative diseases, neurodevelopment, stress response, and behavior. Steroid hormones act on the central and peripheral nervous system and neurons as well as on glial cells. Their biological effects are mediated by the modulation of target genes after the binding to their receptors, but also by rapid non-genomic actions. Nevertheless, the different aspects of steroid biology in the nervous system are still far from well understood.
Steroid hormones influence the function of all organs in mammals. This topic aims to increase the knowledge of steroid receptor actions on the central and peripheral nervous system. It will focus on biological approaches to unravel new mechanisms of action of sex hormones and corticosteroid hormones in the nervous system such as new pathways and target genes in neurons as well as in glial cells. Particular attention will be given to papers providing new understandings and new functions of steroid receptors on pathologies linked to stress, neurodevelopment, neurodegenerative diseases, and behavior. Bringing new knowledge on steroid receptor involvement in nervous system developmental biology may be also of interest. Original articles as well as reviews synthetizing the latest knowledge on one aspect of this field of research are welcome.
The scope of this research topic is to gather articles exploring new avenues concerning:
*Steroid receptors and neurodegenerative diseases;
*Steroid receptors function in glial cells;
*Sex steroid receptor and the male and female nervous system;
*Steroid receptors in nervous system development.
It will include mainly original articles but one or two reviews will be welcome.
