Advances of Brain Metastasis in Breast Cancer

Breast cancer is the most common cancer in women and the second leading cause of cancer-related deaths after lung cancer. Metastasis of the central nervous system is a terrible event for breast cancer patients, affecting their survival and quality of life. The treatment of breast cancer has improved greatly in the last two decades. However, brain metastases from breast cancer remain the leading cause of morbidity and mortality. Patients with breast cancer brain metastasis have been in an inferior position due to the lack of clinical research in this field, and they are often explicitly excluded from almost all clinical trials.

This research topic aims to highlight the recent advances in the treatments of brain metastasis in breast cancer, including the discovery of new targets or agents, novel methods in pre-clinical or clinical trials, as well as deeper insights focusing on the known agents and treatments.

This Research Topic welcomes a wide range of original and review articles, including but not limited to clinical trials, observational studies, qualitative studies, mix-methods studies, systematic reviews, scoping reviews, meta-analyses, and clinical case series, addressing any of the following aspects:

1. Early diagnosis and treatment of central nervous system metastases of breast cancer.

2. Clinical trials on new agents or regimens for brain metastases of breast cancer.

3. Mechanisms of recurrence and resistance to therapy of brain metastases and identification of druggable targets.

4. Treatment strategies for the progression of brain metastases.

5. Development, evaluation, and implementation of innovative interventions for improving symptom outcomes and quality of life in brain metastases survivors.