Advanced Nanomaterials for Diagnostic and Therapeutic Applications: From a Translational Perspective

Editors

Yuqing Li

Institute of Functional Nano and Soft Materials, Soochow University

Zijie Zhang

McMaster University

Xianwen Wang

Anhui Medical University

Yibo Liu

University of Waterloo

Lingzi Ma

School of Medicine, Stanford University

Impact

Hf-based material for immuno-Radiotherapy. (A) nMOF Hf-DBP-Fe enhanced radiotherapy with low-dose X-ray irradiation, leading to highly immunogenic tumor microenvironments for synergistic therapy. Copyright 2020. The Royal Society of Chemistry. (B) Hf-CpG MXF achieved enhanced radiotherapy and further trigger robust tumor-specific immune responses. Copyright 2022, American Chemical Society.

Review

24 November 2023

Advances of hafnium based nanomaterials for cancer theranostics

Jiayi Wang

, 5 more and

Xueliang Liu

4,607 views

11 citations

Transmission electron microscopy images of CDs (A), GA-CDs (B) and GA-CDs@MTX (C), The illustrations are particle size distribution, morphology of solution under fluorescent lamp and ultraviolet lamp; (D) XRD spectrum of CDs; X-ray photoelectron spectroscopy survey spectrum of CDs (E), and XPS spectrum of C1s region (F), N1s region (G), and O1s region (H).

Original Research

23 May 2023

Glycyrrhizic acid modified Poria cocos polyscaccharide carbon dots dissolving microneedles for methotrexate delivery to treat rheumatoid arthritis

Qi Chen

, 6 more and

Ying Xie

5,593 views

17 citations

(A) Hemolytic activity of ZRTs nanoparticles: The extent of damage caused to red blood cells by the ZRT was measured as percent lysis of total erythrocytes used in the individual sample. (B): In vitro cytotoxicity assay: Dose–response effects of ZRTs nanoparticles on cytotoxicity against Vero cells.

Original Research

01 December 2022

Anticancer effect of zinc oxide nanoparticles prepared by varying entry time of ion carriers against A431 skin cancer cells in vitro

Albandri Yousef Aljohar

, 12 more and

Mohd Imran Ahamed

5,786 views

23 citations

Original Research

04 December 2017

Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer

Mi Hyeon Cho

, 3 more and

Yongdoo Choi

In this study, we synthesized manganese dioxide nanoparticles (MnO₂ NPs) stabilized with biocompatible polymers (polyvinylpyrrolidone and polyacrylic acid) and analyzed their effect on non-small cell lung cancer (NSCLC) cells with or without gefitinib resistance in vitro. MnO₂ NPs showed glutathione (GSH)-responsive dissolution and subsequent enhancement in magnetic resonance (MR) imaging. Of note, treatment with MnO₂ NPs induced significant cytotoxic effects on NSCLC cells, and additional dose-dependent therapeutic effects were obtained upon X-ray irradiation. Normal cells treated with MnO₂ NPs were viable at the tested concentrations. In addition, increased therapeutic efficacy could be achieved when the cells were treated with MnO₂ NPs in hypoxic conditions. Therefore, we conclude that the use of MnO₂ NPs in MR imaging and combination radiotherapy may be an efficient strategy for the imaging and therapy of NSCLC.

7,466 views

60 citations