About this Research Topic
Immunometabolism is a field that examines the role of nutrients and energetic substrates on immune cell functions. During chronic diseases state, such as obesity, type 2 diabetes, dyslipidemia, and others, people exhibit metabolic disruption and low-grade inflammation, leading to chaos metabolic and favoring the installation of other conditions like diseases.
Immune cell functions are deeply affected, leading to the hyper-production of pro-inflammatory cytokines, and this can be modulated by energetic metabolism inside cells, in which glycolytic metabolism is predominant, favoring activation of transcriptional factors such as NF-kB, HIF-1 alpha, mTORC1, and others. If these transcriptional factors activated during chronic period may change the immunophenotype of immune cells and leads to premature death, such immunosenescence state.
Non-pharmaceutical and pharmaceutical strategies are adopted to counterpart these conditions. Especially, non-pharmaceutical strategies, as physical exercise and nutrition intervention might be adopted to recover the normal condition. Current studies have shown partial or complete recovery of disruption when obese or type 2 diabetes people are submitted to physical exercise training and nutritional treatments, and when both interventions are combinate the effect might be potentialized.
Pharmaceutical treatments are adopted with a specific target, but in general, have side effects. Current studies have shown minimal side effects and good responses to diseases. Taken together, non-pharmaceutical and pharmaceutical therapies appear t be important interventions, and these treatments might modulate the immune cells, change the energetic metabolism and cytokines production, leading to anti-inflammatory states.
This Frontiers Research Topic seeks a broad range of articles in the following areas:
- The metabolic crosstalk between adipose tissue, skeletal muscle, and immune cells during diseases;
- The relationships between the different myokines and adipokines in response to exercise modulating immunophenotype and energetic metabolism of immune cells;
- The metabolic crosstalk between adipose tissue, skeletal muscle, and immune cells during nutritional and physical exercise interventions;
- Mechanisms involved in the energy balance regulation process, whole body, and inside immune cells.
Thus, this Frontiers Research Topic seeks a broad range of articles in the following areas, and
will accept original research, reviews/mini-reviews, brief research reports, perspectives, clinical
trials, case reports, and opinion articles.
Immune cell functions are deeply affected, leading to the hyper-production of pro-inflammatory cytokines, and this can be modulated by energetic metabolism inside cells, in which glycolytic metabolism is predominant, favoring activation of transcriptional factors such as NF-kB, HIF-1 alpha, mTORC1, and others. If these transcriptional factors activated during chronic period may change the immunophenotype of immune cells and leads to premature death, such immunosenescence state.
Non-pharmaceutical and pharmaceutical strategies are adopted to counterpart these conditions. Especially, non-pharmaceutical strategies, as physical exercise and nutrition intervention might be adopted to recover the normal condition. Current studies have shown partial or complete recovery of disruption when obese or type 2 diabetes people are submitted to physical exercise training and nutritional treatments, and when both interventions are combinate the effect might be potentialized.
Pharmaceutical treatments are adopted with a specific target, but in general, have side effects. Current studies have shown minimal side effects and good responses to diseases. Taken together, non-pharmaceutical and pharmaceutical therapies appear t be important interventions, and these treatments might modulate the immune cells, change the energetic metabolism and cytokines production, leading to anti-inflammatory states.
This Frontiers Research Topic seeks a broad range of articles in the following areas:
- The metabolic crosstalk between adipose tissue, skeletal muscle, and immune cells during diseases;
- The relationships between the different myokines and adipokines in response to exercise modulating immunophenotype and energetic metabolism of immune cells;
- The metabolic crosstalk between adipose tissue, skeletal muscle, and immune cells during nutritional and physical exercise interventions;
- Mechanisms involved in the energy balance regulation process, whole body, and inside immune cells.
Thus, this Frontiers Research Topic seeks a broad range of articles in the following areas, and
will accept original research, reviews/mini-reviews, brief research reports, perspectives, clinical
trials, case reports, and opinion articles.
Keywords: Immunometabolism, Exercise, Nutrition, Immune cells, Pharmacology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
