Autoimmune disease is caused by immune system disorders leading to attacks on own organs. It varies greatly in the organs they affect and in their clinical manifestations, with some being systemic or disseminated and others being limited to particular tissues (i.e. liver or kidney). Studies in humans and experimental animal models reveal that the etiology and pathology of autoimmune diseases are complicated and multifactorial, including genetic, hormonal, environmental factors, and some "unknown trigger factors". Although much progress has been made in understanding the mechanisms of autoimmune disease and the nature of self-tolerance and some benef icial clinical treatments have also been applied to the diseases, autoimmune diseases have proven very challenging to treat, much less to ‘cure’. With the deepening in life sciences and medical research and the invention and application of new technologies, it is increasingly believed that the knowledge of the underlying mechanisms is largely unexplored, and effective and highly targeted treatments have proven elusive. The disease's relatively elusive key points have greatly hindered its drug development and clinical treatment. This issue tries to solicit high-quality papers in exploring the emerging molecular mechanisms and promising intervening strategies involve in autoimmune liver or kidney diseases.
This issue aims not only to collect the emerging studies about molecular mechanisms, but also to discuss the advance of technology and methodology in the field, and also determine how this information might be used to discover novel pharmacological interventions and develop better therapeutic strategies.
This Research Topic has the bullet points as below:
1) Molecular mechanisms involve in autoimmune liver or kidney diseases, including innate immune and adaptive immune signaling
2) Progress of the development of novel drugs, such as antibodies, synthetic molecules, phytochemicals, herbal and traditional Chinese medicines
3) The advance of technology and methodology, such as CRISPR, single-cell sequencing
4) Promising therapeutic strategies
5) Clinical reports on the therapeutics of autoimmune liver or kidney diseases
Autoimmune disease is caused by immune system disorders leading to attacks on own organs. It varies greatly in the organs they affect and in their clinical manifestations, with some being systemic or disseminated and others being limited to particular tissues (i.e. liver or kidney). Studies in humans and experimental animal models reveal that the etiology and pathology of autoimmune diseases are complicated and multifactorial, including genetic, hormonal, environmental factors, and some "unknown trigger factors". Although much progress has been made in understanding the mechanisms of autoimmune disease and the nature of self-tolerance and some benef icial clinical treatments have also been applied to the diseases, autoimmune diseases have proven very challenging to treat, much less to ‘cure’. With the deepening in life sciences and medical research and the invention and application of new technologies, it is increasingly believed that the knowledge of the underlying mechanisms is largely unexplored, and effective and highly targeted treatments have proven elusive. The disease's relatively elusive key points have greatly hindered its drug development and clinical treatment. This issue tries to solicit high-quality papers in exploring the emerging molecular mechanisms and promising intervening strategies involve in autoimmune liver or kidney diseases.
This issue aims not only to collect the emerging studies about molecular mechanisms, but also to discuss the advance of technology and methodology in the field, and also determine how this information might be used to discover novel pharmacological interventions and develop better therapeutic strategies.
This Research Topic has the bullet points as below:
1) Molecular mechanisms involve in autoimmune liver or kidney diseases, including innate immune and adaptive immune signaling
2) Progress of the development of novel drugs, such as antibodies, synthetic molecules, phytochemicals, herbal and traditional Chinese medicines
3) The advance of technology and methodology, such as CRISPR, single-cell sequencing
4) Promising therapeutic strategies
5) Clinical reports on the therapeutics of autoimmune liver or kidney diseases
