Lifestyle interventions especially exercise or physical activities are challenging during both the treatment and prevention of diabetes and other metabolic disorders such as metabolic-associated fatty liver disease (MAFLD). MAFLD is a novel pathological entity comprising patients with fatty liver alongside one of the following clinical conditions: overweight or obesity, T2DM, or evidence of metabolic dysregulation.
Research works have generally agreed that exercise training can have beneficial effects to people with diabetes and MAFLD. To begin with, exercise training has been shown to decrease BM and obesity-associated comorbidities. Moreover, regardless of the types of diabetes, exercise can promote glucose uptake into muscles by a variety of signaling pathways. Insulin sensitivity either in muscles or liver can be greatly improved due to sufficient exercise and can endure up to 72 hours with a substantially reduced level of blood glucose. This powerful effect exhibits an obvious dose-response association with the intensity and duration of exercise. Some studies also revealed that this benefit may result from the improvement of gut microbiota.
In addition, exercise training has also been shown to facilitate metabolic improvements pertinent to lipid profile of obesity models, but effects may vary depending on exercise intensity and volume. Furthermore, aerobic exercise, resistance exercise or combined exercise in terms of the benefits for patients with diabetes and MAFLD have been investigated for a long period of time with heterogeneous findings. The benefits may differ due to age, sex, race, duration, β-cell function, and types of diabetes.
Despite the beneficial effects of applying exercise during the treatment and prevention of diabetes and MAFLD, there are still several gaps in the research field. For instance, studies in terms of the long-term effect of exercise in patients with some specific type of diabetes such as type 1 or during pregnancy are still limited. Therefore, efforts that improve long-term health outcomes are warranted. Apart from that, large-scale clinical trials in patients with diabetes are still needed to understand optimal treatment regimens and the importance of exercise, other lifestyle changes, and medications on glycemia and MAFLD.
This article collection aims to further our understanding on this topic. We would like submissions which address the following sub-topic:
- Exercise in patients with gestational diabetes
- Long-term postpartum effects of exercise in patients with gestational diabetes
- Exercise in patients with type 1 diabetes
- Exercise, gut microbiota and diabetes
- Remote management in patients with diabetes
- Traditional Chinese regimen of exercise (Ba Duan Jin, Qi Gong, etc) and diabetes
- Effects of exercise of different intensity or duration on the treatment and prevention of diabetes
- Sex-specific regimens of exercise with diabetes
- Age-specific regimens of exercise with diabetes
- Exercise and diabetes among older adults with frailty
- Exercise and diabetes complicated with MAFLD
Lifestyle interventions especially exercise or physical activities are challenging during both the treatment and prevention of diabetes and other metabolic disorders such as metabolic-associated fatty liver disease (MAFLD). MAFLD is a novel pathological entity comprising patients with fatty liver alongside one of the following clinical conditions: overweight or obesity, T2DM, or evidence of metabolic dysregulation.
Research works have generally agreed that exercise training can have beneficial effects to people with diabetes and MAFLD. To begin with, exercise training has been shown to decrease BM and obesity-associated comorbidities. Moreover, regardless of the types of diabetes, exercise can promote glucose uptake into muscles by a variety of signaling pathways. Insulin sensitivity either in muscles or liver can be greatly improved due to sufficient exercise and can endure up to 72 hours with a substantially reduced level of blood glucose. This powerful effect exhibits an obvious dose-response association with the intensity and duration of exercise. Some studies also revealed that this benefit may result from the improvement of gut microbiota.
In addition, exercise training has also been shown to facilitate metabolic improvements pertinent to lipid profile of obesity models, but effects may vary depending on exercise intensity and volume. Furthermore, aerobic exercise, resistance exercise or combined exercise in terms of the benefits for patients with diabetes and MAFLD have been investigated for a long period of time with heterogeneous findings. The benefits may differ due to age, sex, race, duration, β-cell function, and types of diabetes.
Despite the beneficial effects of applying exercise during the treatment and prevention of diabetes and MAFLD, there are still several gaps in the research field. For instance, studies in terms of the long-term effect of exercise in patients with some specific type of diabetes such as type 1 or during pregnancy are still limited. Therefore, efforts that improve long-term health outcomes are warranted. Apart from that, large-scale clinical trials in patients with diabetes are still needed to understand optimal treatment regimens and the importance of exercise, other lifestyle changes, and medications on glycemia and MAFLD.
This article collection aims to further our understanding on this topic. We would like submissions which address the following sub-topic:
- Exercise in patients with gestational diabetes
- Long-term postpartum effects of exercise in patients with gestational diabetes
- Exercise in patients with type 1 diabetes
- Exercise, gut microbiota and diabetes
- Remote management in patients with diabetes
- Traditional Chinese regimen of exercise (Ba Duan Jin, Qi Gong, etc) and diabetes
- Effects of exercise of different intensity or duration on the treatment and prevention of diabetes
- Sex-specific regimens of exercise with diabetes
- Age-specific regimens of exercise with diabetes
- Exercise and diabetes among older adults with frailty
- Exercise and diabetes complicated with MAFLD