The role for post transcriptional gene regulation (PTGR) is to mediate the maturation, transport and alternative splicing of coding and non-coding RNAs, as well as their subcellular localization, stability and translation. RNA processing and PTGR are coordinated by RNA-binding proteins (RBPs) and ribonucleoproteins.
Deregulation of gene expression is one of the hallmarks of cancer cells. Deregulation of RNA-RBP interactions or disruptions in RBP expression or function can lead to various diseases, including cancer. It has been demonstrated that RBPs regulate the expression of tumor suppressors and oncoproteins involved in various cell-signaling pathways in cancer cells. As a result, RBPs and their associated pathways can be used for cancer treatment as potential therapeutic targets.
RBP dysregulation has been linked to a number of cancer-related phenotypes, including proliferation, apoptosis, angiogenesis, epithelial-mesenchymal transition (EMT), invasion, metastasis, DNA repair, autophagy, immune responses and metabolism. The regulation of RBP is also linked to cancer prognosis. However, the mechanistic basis of RBP-dependent regulation remains largely unknown.
This Research Topic aims to compile a comprehensive list of articles on “RNA-Binding Proteins in Cancer: Function and Gene Regulation”. First, we will investigate RBPs that are abnormally expressed or deregulated in cancer. Secondly, the role of RBPs in cancer progression should be investigated, along with the mechanisms by which they work. Finally, we will explore RBPs as therapeutic targets for cancer therapy. This collection will cover basic, translational and clinical aspects of cancer research.
Authors are invited to submit Original Research articles, Reviews and Mini-reviews on a wide range of subtopics, including, but not limited to:
- Global analysis of RBPs and their RNA targets;
- RNA-protein interaction networks and their connections to other levels of cellular control;
- Basic, translational, or clinical findings describing the association of RBPs with cancer;
- Therapeutic interventions in cancer to treat RBP deregulation or dysfunction;
- New techniques for investigating RNA-binding proteins and RNA/DNA secondary structures;
- Molecular functions of RBPs in post-transcriptional gene expression control (including coding and non-coding RNAs) and translational control.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
The role for post transcriptional gene regulation (PTGR) is to mediate the maturation, transport and alternative splicing of coding and non-coding RNAs, as well as their subcellular localization, stability and translation. RNA processing and PTGR are coordinated by RNA-binding proteins (RBPs) and ribonucleoproteins.
Deregulation of gene expression is one of the hallmarks of cancer cells. Deregulation of RNA-RBP interactions or disruptions in RBP expression or function can lead to various diseases, including cancer. It has been demonstrated that RBPs regulate the expression of tumor suppressors and oncoproteins involved in various cell-signaling pathways in cancer cells. As a result, RBPs and their associated pathways can be used for cancer treatment as potential therapeutic targets.
RBP dysregulation has been linked to a number of cancer-related phenotypes, including proliferation, apoptosis, angiogenesis, epithelial-mesenchymal transition (EMT), invasion, metastasis, DNA repair, autophagy, immune responses and metabolism. The regulation of RBP is also linked to cancer prognosis. However, the mechanistic basis of RBP-dependent regulation remains largely unknown.
This Research Topic aims to compile a comprehensive list of articles on “RNA-Binding Proteins in Cancer: Function and Gene Regulation”. First, we will investigate RBPs that are abnormally expressed or deregulated in cancer. Secondly, the role of RBPs in cancer progression should be investigated, along with the mechanisms by which they work. Finally, we will explore RBPs as therapeutic targets for cancer therapy. This collection will cover basic, translational and clinical aspects of cancer research.
Authors are invited to submit Original Research articles, Reviews and Mini-reviews on a wide range of subtopics, including, but not limited to:
- Global analysis of RBPs and their RNA targets;
- RNA-protein interaction networks and their connections to other levels of cellular control;
- Basic, translational, or clinical findings describing the association of RBPs with cancer;
- Therapeutic interventions in cancer to treat RBP deregulation or dysfunction;
- New techniques for investigating RNA-binding proteins and RNA/DNA secondary structures;
- Molecular functions of RBPs in post-transcriptional gene expression control (including coding and non-coding RNAs) and translational control.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
