Epigenetic modifications play a very important role in regulating the expression of genes, mainly including DNA methylation and histone modifications. Studies have shown that a variety of environmental factors are closely related to osteoporosis and other bone metabolism-related diseases, epigenetic factors have a great influence on the differentiation and activity of bone cells, and are associated with the pathogenesis of bone metabolic-related diseases.
Based on the multi-omics life big data research method, it can understand the interaction between genetics, epigenetics, gene expression, metabolism, and the environment from a multi-dimensional system, to play an important role in individualized prevention, treatment, and medication guidance, so it is the future research direction of complex diseases such as bone metabolism abnormalities. In the future, it is necessary to synthesize the multi-omics molecular markers including heredity and epigenetics found in the previous research, construct a new risk assessment model covering genetic-environmental-aging dynamics, and supplement it with precise individual intervention programs to reduce the recurrence rate, and finally realize the early screening and efficient prevention and treatment of bone metabolism-related diseases
• Epigenetic mechanism in bone metabolism-related diseases
• The functions of genetic-environmental-aging dynamics in bone metabolism, bone development, and bone homeostasis;
• The potential molecular markers for prognosis, prevention, and drug targets for bone metabolism-related diseases and bone density;
• The therapeutic strategy for osteoporosis and other bone metabolism-related diseases;
• The study on the genetic loci of osteoporosis and other bone metabolism-related diseases;
• Genome-wide association analysis studies of osteoporosis or bone density phenotypes.
Epigenetic modifications play a very important role in regulating the expression of genes, mainly including DNA methylation and histone modifications. Studies have shown that a variety of environmental factors are closely related to osteoporosis and other bone metabolism-related diseases, epigenetic factors have a great influence on the differentiation and activity of bone cells, and are associated with the pathogenesis of bone metabolic-related diseases.
Based on the multi-omics life big data research method, it can understand the interaction between genetics, epigenetics, gene expression, metabolism, and the environment from a multi-dimensional system, to play an important role in individualized prevention, treatment, and medication guidance, so it is the future research direction of complex diseases such as bone metabolism abnormalities. In the future, it is necessary to synthesize the multi-omics molecular markers including heredity and epigenetics found in the previous research, construct a new risk assessment model covering genetic-environmental-aging dynamics, and supplement it with precise individual intervention programs to reduce the recurrence rate, and finally realize the early screening and efficient prevention and treatment of bone metabolism-related diseases
• Epigenetic mechanism in bone metabolism-related diseases
• The functions of genetic-environmental-aging dynamics in bone metabolism, bone development, and bone homeostasis;
• The potential molecular markers for prognosis, prevention, and drug targets for bone metabolism-related diseases and bone density;
• The therapeutic strategy for osteoporosis and other bone metabolism-related diseases;
• The study on the genetic loci of osteoporosis and other bone metabolism-related diseases;
• Genome-wide association analysis studies of osteoporosis or bone density phenotypes.
