About this Research Topic
Acute kidney injury (AKI), a highly heterogeneous clinical syndrome of acute impairment of the kidney, is characterized by an abrupt rise in serum creatinine concentration and a decrease in urinary output within a few hours for up to a few days. It is reported that many patients die from it worldwide each year. However, there are currently no therapeutic drugs for treating and preventing AKI, owing to the poor understanding of the pathogenesis of AKI. Therefore, a better understanding of the cellular and molecular mechanisms of AKI is essential and urgently required for the development of therapeutic drugs against AKI in clinics.
Traditional medical herb has a long history of preventing and treating AKI in clinics. Recently, more and more chemicals derived from traditional medical herbs effectively prevent AKI by alleviating kidney inflammation, oxidative stress, and apoptosis. These active compounds serve as inhibitors of the significant signaling pathways involved in AKI. Some of them have shown their efficiency in clinics, such as anisodamine, an alkaloid derived from Anisodus tanguticus (Maxim.) Pascher. These cases show a promising prospect in finding therapy drugs against AKI from traditional medicinal herbs. However, the active ingredients and mechanisms of traditional medical herbs against AKI are still poorly understood.
This Research Topic aims at collecting the manuscripts demonstrating the novel findings in the pathological process of AKI and the renoprotective effects of compounds derived from traditional medical herbs against AKI.
Potential topics include but are not limited to the following:
• Novel findings in the pathogenesis of AKI.
• Novel biomarkers for the early diagnosis of AKI.
• Novel animal models of AKI.
• Novel therapeutic targets and strategies of AKI.
• The roles of gut microbiota in AKI.
• Research on AKI based on omics technology.
• The mechanisms of traditional medical herbs against AKI.
• Compounds derived from traditional medical herbs against AKI.
Original research articles, review articles, and short communications will be accepted for this Research Topic.
Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Only compounds with clear chemical structures from traditional medical herbs will be considered in this project. Plant extracts are not suitable for this issue. Frontiers reserve the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Traditional medical herb has a long history of preventing and treating AKI in clinics. Recently, more and more chemicals derived from traditional medical herbs effectively prevent AKI by alleviating kidney inflammation, oxidative stress, and apoptosis. These active compounds serve as inhibitors of the significant signaling pathways involved in AKI. Some of them have shown their efficiency in clinics, such as anisodamine, an alkaloid derived from Anisodus tanguticus (Maxim.) Pascher. These cases show a promising prospect in finding therapy drugs against AKI from traditional medicinal herbs. However, the active ingredients and mechanisms of traditional medical herbs against AKI are still poorly understood.
This Research Topic aims at collecting the manuscripts demonstrating the novel findings in the pathological process of AKI and the renoprotective effects of compounds derived from traditional medical herbs against AKI.
Potential topics include but are not limited to the following:
• Novel findings in the pathogenesis of AKI.
• Novel biomarkers for the early diagnosis of AKI.
• Novel animal models of AKI.
• Novel therapeutic targets and strategies of AKI.
• The roles of gut microbiota in AKI.
• Research on AKI based on omics technology.
• The mechanisms of traditional medical herbs against AKI.
• Compounds derived from traditional medical herbs against AKI.
Original research articles, review articles, and short communications will be accepted for this Research Topic.
Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Only compounds with clear chemical structures from traditional medical herbs will be considered in this project. Plant extracts are not suitable for this issue. Frontiers reserve the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Keywords: Acute Kidney Injury, Pathological Mechanism, Phytotherapy, Phytomedicine, Bioactive Ingredient
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
