In the last years, extensive findings have provided the importance of communication systems between metabolic tissues in order to modulate energy homeostasis and metabolism. One main organ involved on this, is the adipose tissue, which secretes different factors called adipokines or batokines, originated in white and brown adipose tissue respectively. These factors (including peptides, metabolite, lipids or microRNAs) play an autocrine, paracrine and endocrine role, establishing communications with other cell types (immune cells) and key metabolic organs. However, more research is needed to decipher how these adipose tissue factors modulate cardiac function, skeletal muscle performance, liver metabolism and crosstalk with central and peripheral nervous system. This Research Topic aims to provide new insights on underlying mechanisms involved in the metabolic crosstalk between white and brown adipose tissues with the liver, heart, muscle and central/peripheral nervous systems. The goal is to investigate how this communication may impact the progression of pathologies such as obesity, diabetes, NAFLD and cardiovascular diseases. Adipokines and batokines are novel candidates to develop new therapeutic strategies for the treatment of metabolic syndrome. We welcome Original Research articles and Reviews on the subtopics below, with a particular interest on animal and human research, but ex-vivo and in-vitro studies will also be considered. • New inter-communication signals/pathways between adipose tissues.• Adipokines/batokines in glucose and lipid metabolism.• Novel adipokines/batokines controlling fat mass and body weight: therapeutic approaches. • Adipose tissues and immune cells crosstalk: adipokines/batokinees/cytokines.• Adipokines and circadian clock.• Adipokines/ batokines and peripheral nervous sytem crosstalk.• Epicardial adipose tissue and cardiac function• Getting to the heart of tissue-cross talk- the role of cardiokines
In the last years, extensive findings have provided the importance of communication systems between metabolic tissues in order to modulate energy homeostasis and metabolism. One main organ involved on this, is the adipose tissue, which secretes different factors called adipokines or batokines, originated in white and brown adipose tissue respectively. These factors (including peptides, metabolite, lipids or microRNAs) play an autocrine, paracrine and endocrine role, establishing communications with other cell types (immune cells) and key metabolic organs. However, more research is needed to decipher how these adipose tissue factors modulate cardiac function, skeletal muscle performance, liver metabolism and crosstalk with central and peripheral nervous system. This Research Topic aims to provide new insights on underlying mechanisms involved in the metabolic crosstalk between white and brown adipose tissues with the liver, heart, muscle and central/peripheral nervous systems. The goal is to investigate how this communication may impact the progression of pathologies such as obesity, diabetes, NAFLD and cardiovascular diseases. Adipokines and batokines are novel candidates to develop new therapeutic strategies for the treatment of metabolic syndrome. We welcome Original Research articles and Reviews on the subtopics below, with a particular interest on animal and human research, but ex-vivo and in-vitro studies will also be considered. • New inter-communication signals/pathways between adipose tissues.• Adipokines/batokines in glucose and lipid metabolism.• Novel adipokines/batokines controlling fat mass and body weight: therapeutic approaches. • Adipose tissues and immune cells crosstalk: adipokines/batokinees/cytokines.• Adipokines and circadian clock.• Adipokines/ batokines and peripheral nervous sytem crosstalk.• Epicardial adipose tissue and cardiac function• Getting to the heart of tissue-cross talk- the role of cardiokines