The impact of female hormones on mood and cognition is increasingly recognized. The increased risk of depressive symptomatology during specific phases of women’s reproductive life is well established with psychiatric diagnoses of premenstrual dysphoric disorder, postpartum depression and perimenopausal depression. Fluctuations of female hormones have been associated with this increased risk and have led to some new therapeutic options. For example, brexanolone, an exogenous formulation of allopregnanolone, the main metabolite of progesterone, has been approved for the treatment of postpartum depression.
The female hormonal changes occurring across the life span of women have also been associated with an impact on cognition. A particular topic of interest is the increased risk of Alzheimer disease in women versus men.
Unfortunately, there is a dearth of knowledge regarding the impact of female hormones on the brain.
This research topic aims at reviewing the evidence of the impact of female hormones on mood and cognition. It also aims at reviewing the research data that shows the impact of female hormones on the brain at the macro and cellular levels. Finally, the research topic aims at assessing how this greater knowledge of the impact of female hormones on the brain opens therapeutic avenues for the treatment of psychiatric disorders and neurocognitive disorders.
Particular themes of interest are, but not limited to:
-Mood disorders across women’s reproductive life
-Influence of female gender on cognition
-Impact of female hormones on the brain: neuroimaging studies
-Impact of female hormones on the brain at the cellular level
-Possible therapeutic options for psychiatric disorders based on female hormone activity on the brain
-Therapeutic options for improving cognition based on female hormone activity on the brain
The impact of female hormones on mood and cognition is increasingly recognized. The increased risk of depressive symptomatology during specific phases of women’s reproductive life is well established with psychiatric diagnoses of premenstrual dysphoric disorder, postpartum depression and perimenopausal depression. Fluctuations of female hormones have been associated with this increased risk and have led to some new therapeutic options. For example, brexanolone, an exogenous formulation of allopregnanolone, the main metabolite of progesterone, has been approved for the treatment of postpartum depression.
The female hormonal changes occurring across the life span of women have also been associated with an impact on cognition. A particular topic of interest is the increased risk of Alzheimer disease in women versus men.
Unfortunately, there is a dearth of knowledge regarding the impact of female hormones on the brain.
This research topic aims at reviewing the evidence of the impact of female hormones on mood and cognition. It also aims at reviewing the research data that shows the impact of female hormones on the brain at the macro and cellular levels. Finally, the research topic aims at assessing how this greater knowledge of the impact of female hormones on the brain opens therapeutic avenues for the treatment of psychiatric disorders and neurocognitive disorders.
Particular themes of interest are, but not limited to:
-Mood disorders across women’s reproductive life
-Influence of female gender on cognition
-Impact of female hormones on the brain: neuroimaging studies
-Impact of female hormones on the brain at the cellular level
-Possible therapeutic options for psychiatric disorders based on female hormone activity on the brain
-Therapeutic options for improving cognition based on female hormone activity on the brain
