The immune microenvironment in the brain is insulated by the blood-brain barrier (BBB) and has unique cell components, which leads to a relatively immune-privileged microenvironment. Growing evidence has demonstrated that the immune microenvironment plays an important role in the onset, progression, and prognosis of different cerebrovascular diseases affecting blood flow and the blood vessels in the brain, such as stroke, vascular brain tumors, and carotid artery disease amongst others. Targeting the immune microenvironment has emerged as an effective strategy for the treatment of these diseases. However, the subpopulations and molecular components of the dynamic immune microenvironment demand further characterization. Therapeutic strategies targeting the immune cerebrovascular microenvironment need exploration for translational medicine as the administration of immunotherapy has not shown obvious survival benefits in patients suffering from these disorders.
The immune landscape and inflammatory response participate in the whole process of cerebrovascular diseases and vascular inflammation. The aim of this Research Topic is to gather comprehensive studies related to the immune microenvironment in diseases involving brain blood vessel disorders. This collection will try to dissect the gene expression landscapes, cellular subpopulations, critical functional molecules as well as corresponding regulatory mechanisms of the immune microenvironment in the context of these types of diseases. Translational medicine and the therapeutic strategies targeting different immune components will be explored on the basis of a better understanding of the immune microenvironment of these diseases.
We welcome submissions of Original Research articles, Reviews, and Mini-reviews, including but not limited to the following subtopics:
• Analysis and identification of cellular and molecular components of the immune microenvironment in cerebrovascular diseases.
• Identification of immune-related genes associated with the progression of cerebrovascular diseases, thus providing clues for the development of new therapeutic targets.
• Analysis and intervention solutions of harsh immune microenvironment related to (1) tissue recovery and neural regeneration after cerebrovascular diseases; (2) immune evasion, drug resistance, and recurrence.
• Drugs and immunotherapy strategies targeting the immunological microenvironment in cerebrovascular diseases.
The immune microenvironment in the brain is insulated by the blood-brain barrier (BBB) and has unique cell components, which leads to a relatively immune-privileged microenvironment. Growing evidence has demonstrated that the immune microenvironment plays an important role in the onset, progression, and prognosis of different cerebrovascular diseases affecting blood flow and the blood vessels in the brain, such as stroke, vascular brain tumors, and carotid artery disease amongst others. Targeting the immune microenvironment has emerged as an effective strategy for the treatment of these diseases. However, the subpopulations and molecular components of the dynamic immune microenvironment demand further characterization. Therapeutic strategies targeting the immune cerebrovascular microenvironment need exploration for translational medicine as the administration of immunotherapy has not shown obvious survival benefits in patients suffering from these disorders.
The immune landscape and inflammatory response participate in the whole process of cerebrovascular diseases and vascular inflammation. The aim of this Research Topic is to gather comprehensive studies related to the immune microenvironment in diseases involving brain blood vessel disorders. This collection will try to dissect the gene expression landscapes, cellular subpopulations, critical functional molecules as well as corresponding regulatory mechanisms of the immune microenvironment in the context of these types of diseases. Translational medicine and the therapeutic strategies targeting different immune components will be explored on the basis of a better understanding of the immune microenvironment of these diseases.
We welcome submissions of Original Research articles, Reviews, and Mini-reviews, including but not limited to the following subtopics:
• Analysis and identification of cellular and molecular components of the immune microenvironment in cerebrovascular diseases.
• Identification of immune-related genes associated with the progression of cerebrovascular diseases, thus providing clues for the development of new therapeutic targets.
• Analysis and intervention solutions of harsh immune microenvironment related to (1) tissue recovery and neural regeneration after cerebrovascular diseases; (2) immune evasion, drug resistance, and recurrence.
• Drugs and immunotherapy strategies targeting the immunological microenvironment in cerebrovascular diseases.