The stomach has a unique and complex microecology. The microbial diversity and abundance alterations relate to a variety of gastric diseases. When it comes to stomach disease-related microorganisms, the most well-known bacteria species is Helicobacter pylori. However, the non-H. pylori-associated occurrence and development of gastric diseases, especially gastric cancer, has been gradually recognized in recent years. Species that are considered to be symbiotic or beneficial microorganisms are also associated with disease when they exceed certain limits. Furthermore, the eradication of H.pylori, believed to be the culprit of many stomach diseases, has encountered obstacles with antibiotic resistance. Besides, different microorganisms may have synergistic, neutral, and antagonistic effects through communication with each other.
Disorders of gastric microecology are associated with a variety of gastric diseases, but the causal relationship between them is still unclear. Previous research on gastric diseases has focused on bacteria, while viruses and eukaryotic microorganisms like fungi have been ignored. Thus, a correct and comprehensive understanding of the gastric microbiome composition and function (independent pathogenic mechanisms, or interactions between functional groups) is necessary, which may provide a new horizon for the diagnosis and treatment of human gastric diseases.
This Research Topic welcomes Original Research articles, reviews, mini-reviews, etc., related to gastric microbiota dysbiosis and gastric diseases. Sub-topic can be, but are not limited to:
• Analysis of fungi, other eukaryotic microorganisms, and viruses community in gastric microecology under physiological/disease conditions.
• The role of gastric microorganisms (including non-H.pylori bacteria, fungi, and viruses) in human gastric diseases.
• Mechanism of gastric microbial interactions, such as the interaction between probiotics and pathogens, interaction between bacteria and viruses, and interaction between bacteria and fungi.
• The mechanism of drug resistance of H.pylori; finding a new way to improve the rate of H.pylori eradication or the critical point of symbiosis between the host and H.pylori.
• Taking gastric microecology as the therapeutic target and treating gastric diseases by regulating gastric microecology.
• The exploration of the feasibility and specific methods of gastric microecological transplantation.
The stomach has a unique and complex microecology. The microbial diversity and abundance alterations relate to a variety of gastric diseases. When it comes to stomach disease-related microorganisms, the most well-known bacteria species is Helicobacter pylori. However, the non-H. pylori-associated occurrence and development of gastric diseases, especially gastric cancer, has been gradually recognized in recent years. Species that are considered to be symbiotic or beneficial microorganisms are also associated with disease when they exceed certain limits. Furthermore, the eradication of H.pylori, believed to be the culprit of many stomach diseases, has encountered obstacles with antibiotic resistance. Besides, different microorganisms may have synergistic, neutral, and antagonistic effects through communication with each other.
Disorders of gastric microecology are associated with a variety of gastric diseases, but the causal relationship between them is still unclear. Previous research on gastric diseases has focused on bacteria, while viruses and eukaryotic microorganisms like fungi have been ignored. Thus, a correct and comprehensive understanding of the gastric microbiome composition and function (independent pathogenic mechanisms, or interactions between functional groups) is necessary, which may provide a new horizon for the diagnosis and treatment of human gastric diseases.
This Research Topic welcomes Original Research articles, reviews, mini-reviews, etc., related to gastric microbiota dysbiosis and gastric diseases. Sub-topic can be, but are not limited to:
• Analysis of fungi, other eukaryotic microorganisms, and viruses community in gastric microecology under physiological/disease conditions.
• The role of gastric microorganisms (including non-H.pylori bacteria, fungi, and viruses) in human gastric diseases.
• Mechanism of gastric microbial interactions, such as the interaction between probiotics and pathogens, interaction between bacteria and viruses, and interaction between bacteria and fungi.
• The mechanism of drug resistance of H.pylori; finding a new way to improve the rate of H.pylori eradication or the critical point of symbiosis between the host and H.pylori.
• Taking gastric microecology as the therapeutic target and treating gastric diseases by regulating gastric microecology.
• The exploration of the feasibility and specific methods of gastric microecological transplantation.