Axonopathy in Neurodegenerative Disease

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Editorial

23 October 2018

Editorial: Axonopathy in Neurodegenerative Disease

Robert W. Burgess

and

Samuel D. Crish

11,326 views

8 citations

Editors

6

Samuel David Crish

Northeast Ohio Medical University

North Texas Eye Research Institute, University of North Texas Health Science Center

Christine M Dengler-Crish

Northeast Ohio Medical University

Brett R Schofield

Northeast Ohio Medical University

Jason R Richardson

Florida International University

Robert W. Burgess

Jackson Laboratory

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Axons are the major output processes of neurons. Normal axonal function is due to a complex relationship between a constellation of signaling molecules, molecular motors, mitochondria, structural elements, and ion channels of axons and glia. Recently, axonopathy, broadly defined as functional or structural defects in the axon or its terminal, has been established as a major early contributor to the genesis, progression, and symptomology of neurodegenerative disorders. These changes are common across a wide range of neurodegenerations including amyotrophic lateral sclerosis, Huntington’s, Parkinson’s, and Alzheimer’s diseases, glaucoma, and as a result of neurotoxin exposure. Despite the varied locations and progression of these conditions, axonal pathologies share many features.

The aim of this research topic is to assemble a series of original research papers, reviews, and commentaries that will illustrate both the commonalities and important differences across these diseases so that we may better understand and investigate this important topic.

Axons are the major output processes of neurons. Normal axonal function is due to a complex relationship between a constellation of signaling molecules, molecular motors, mitochondria, structural elements, and ion channels of axons and glia. Recently, axonopathy, broadly defined as functional or structural defects in the axon or its terminal, has been established as a major early contributor to the genesis, progression, and symptomology of neurodegenerative disorders. These changes are common across a wide range of neurodegenerations including amyotrophic lateral sclerosis, Huntington’s, Parkinson’s, and Alzheimer’s diseases, glaucoma, and as a result of neurotoxin exposure. Despite the varied locations and progression of these conditions, axonal pathologies share many features.

The aim of this research topic is to assemble a series of original research papers, reviews, and commentaries that will illustrate both the commonalities and important differences across these diseases so that we may better understand and investigate this important topic.

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Editors

Samuel David Crish

Northeast Ohio Medical University

North Texas Eye Research Institute, University of North Texas Health Science Center

Christine M Dengler-Crish

Northeast Ohio Medical University

Brett R Schofield

Northeast Ohio Medical University

Jason R Richardson

Florida International University

Robert W. Burgess

Jackson Laboratory

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193,519 Total views

147,439 Article views

32,733 Article downloads

13,347 Topic views

Published In

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Frontiers in Neuroscience

Neurodegeneration

Journal Thumbnail

Frontiers in Psychiatry

Neurodegeneration

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Frontiers in Neurology

Neurodegeneration

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