About this Research Topic
Whilst oxygen sensing was once thought to be the competence of highly specialized and dedicated cells (i.e., glomus cells of the carotid body), we now acknowledge that all cells respond to hypoxia to a greater or lesser extent, which translates into HIF-mediated transcription regulation for cell-adaptive purposes.
Erythropoietin production still stands as the paradigm of oxygen-dependent transcription regulation (HIF-EPO axis). Furthermore, HIF promotes erythropoiesis through coordinated cell type-specific hypoxia responses, leading to enhanced iron uptake and utilization, as well as changes in the bone marrow microenvironment that facilitate erythroid progenitor maturation and proliferation. Beyond that, hematopoietic cells (starting from the stem cell), which preferentially locates into hypoxic areas within the bone marrow niche, passes through committed progenitors, ending up into mature cells. They all have a very sensible oxygen-sensing machinery and different mechanisms to overcome, which for other cell types would be an overt oxidative stress.
Understanding the intricate relationship of oxygen - and redox - sensing around erythropoiesis - in health and disease - is of utmost importance to advance the knowledge and to better treat the wide range of erythroid-related pathologies where these processes are affected.
Original articles and reviews should be submitted, whereby an intersectional approach is encouraged. We would like to gather a compendium of comprehensive studies established from different perspectives, disciplines or research type (basic and/or translational-clinical) incorporating classic and new experimental approaches, integrated (i.e., from blood complete counts to multi-omics).
Erythropoietin production still stands as the paradigm of oxygen-dependent transcription regulation (HIF-EPO axis). Furthermore, HIF promotes erythropoiesis through coordinated cell type-specific hypoxia responses, leading to enhanced iron uptake and utilization, as well as changes in the bone marrow microenvironment that facilitate erythroid progenitor maturation and proliferation. Beyond that, hematopoietic cells (starting from the stem cell), which preferentially locates into hypoxic areas within the bone marrow niche, passes through committed progenitors, ending up into mature cells. They all have a very sensible oxygen-sensing machinery and different mechanisms to overcome, which for other cell types would be an overt oxidative stress.
Understanding the intricate relationship of oxygen - and redox - sensing around erythropoiesis - in health and disease - is of utmost importance to advance the knowledge and to better treat the wide range of erythroid-related pathologies where these processes are affected.
Original articles and reviews should be submitted, whereby an intersectional approach is encouraged. We would like to gather a compendium of comprehensive studies established from different perspectives, disciplines or research type (basic and/or translational-clinical) incorporating classic and new experimental approaches, integrated (i.e., from blood complete counts to multi-omics).
Keywords: Oxygen Sensing, Oxidative Stress, Reactive Oxygen Species (ROS), HIFs, VHL, Iron, Erythropoiesis, Erythropoietin, Hematopoiesis, Hematopoietic Stem Cell, Erythocytosis, (Chuvash) Polycythemia, Malignancy, Renal Failure, Novel Therapies
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