For decades, the increasing incidence of reproductive diseases in the population has become a growing global problem. DNA damage can seriously affect the reproductive capacity of mammals, leading to reproductive diseases. Therefore, DNA damage repair plays an important role in maintaining reproductive capacity, preventing and treating reproductive diseases. In female patients, the normal growth and development of oocytes and granulosa cells associated with egg formation require the involvement of DNA damage repair pathways. Activated successfully by the DNA damage repair pathway, oocytes can ensure the successful completion of the meiosis process, thus guaranteeing the normal development of oocytes. The DNA damage repair pathway can also repair DNA damage in granulosa cells and hinder the aging and apoptosis process of which caused by DNA damage. Correspondingly, the normal completion of meiosis related to spermatogenesis in male patients is also inseparable from the DNA damage repair pathway.

It is well known that DNA damage is affected by both endogenous and exogenous factors, whose repair pathways include a series of repair mechanisms, such as direct repair and mismatch repair. Blocked DNA damage repair pathways can lead to germ cell genome instability and cell defects, causing reproductive diseases. However, the current research on the functional mechanism of DNA damage repair is not comprehensive, and the specific function in reproductive diseases is not clear. Therefore, it is necessary to further explore the related pathways of DNA damage repair and the mechanism and function of DNA damage repair in reproductive diseases.

This Research Topic aims to highlight recent achievements in the field of DNA damage repair in reproductive diseases and explore the underlying mechanisms that establish the role of DNA damage repair.

We welcome submissions of Original Research articles, Reviews, Mini-Review and Systematic Review articles that focused on, but are not limited to, the following topics:
• Mechanisms of abnormal DNA damage repair regulating follicular development or spermatogenesis.
• Mechanisms of abnormal DNA damage repair regulating ovarian cancer occurrence and development.
• Treatment of abnormal DNA damage repair in reproductive diseases.
• Drug development related to abnormal DNA damage repair in reproductive diseases.
• Extracellular vesicles as cellular messengers in DNA damage repair in reproductive diseases.

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Frontiers in Endocrinology

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