Given the success of
Volume I of this Research Topic, and how rapid the subject area is evolving, we are pleased to announce the launch of Ferroptosis in Cancer and Beyond - Volume II
Ferroptosis, a newly identified type of regulated cell death, is caused by the unchecked oxidative perturbation within the cell. Since its discovery, ferroptosis has gained substantial attention in both basic research and clinical applications. Ferroptosis is associated with a variety of physiological or pathological processes, such as normal development, ischemic injuries, degenerative diseases, immune system activities, and remarkably is also involved in tumor biology. The physio-pathological relevance of ferroptosis makes it an attractive therapeutic target to cure different diseases. Numerous cellular factors and potential regulatory pathways underlying ferroptosis have been elucidated. However, new mechanisms and clinical relevance of ferroptosis are still emerging.
The aim of this Research Topic is to report on the basic mechanisms underlying ferroptosis, how ferroptosis is regulated, and how ferroptosis pathways can be targeted therapeutically. We will pay extra attention to these papers about novel/non-canonical ferroptosis pathways. We also expect research identifying existing or new drugs that target the ferroptosis pathway in diverse diseases, particularly tumors.
Original Research Articles, Reviews, and Mini-Reviews are welcome to submit to this Research Topic. Papers are expected to cover but are not limited to the following topics:
(1) Basic mechanism and novel regulators of ferroptosis.
(2) Role of p53 in both canonical and non-canonical ferroptosis regulation.
(3) Targeting ferroptosis for disease (including tumor, neurodegenerative diseases, ischemic organ injury, dysregulated cell oxidative response, and immune cell function) treatment.
Please note that the findings based on bioinformatic data mining should be better validated by experiments.
Given the success of
Volume I of this Research Topic, and how rapid the subject area is evolving, we are pleased to announce the launch of Ferroptosis in Cancer and Beyond - Volume II
Ferroptosis, a newly identified type of regulated cell death, is caused by the unchecked oxidative perturbation within the cell. Since its discovery, ferroptosis has gained substantial attention in both basic research and clinical applications. Ferroptosis is associated with a variety of physiological or pathological processes, such as normal development, ischemic injuries, degenerative diseases, immune system activities, and remarkably is also involved in tumor biology. The physio-pathological relevance of ferroptosis makes it an attractive therapeutic target to cure different diseases. Numerous cellular factors and potential regulatory pathways underlying ferroptosis have been elucidated. However, new mechanisms and clinical relevance of ferroptosis are still emerging.
The aim of this Research Topic is to report on the basic mechanisms underlying ferroptosis, how ferroptosis is regulated, and how ferroptosis pathways can be targeted therapeutically. We will pay extra attention to these papers about novel/non-canonical ferroptosis pathways. We also expect research identifying existing or new drugs that target the ferroptosis pathway in diverse diseases, particularly tumors.
Original Research Articles, Reviews, and Mini-Reviews are welcome to submit to this Research Topic. Papers are expected to cover but are not limited to the following topics:
(1) Basic mechanism and novel regulators of ferroptosis.
(2) Role of p53 in both canonical and non-canonical ferroptosis regulation.
(3) Targeting ferroptosis for disease (including tumor, neurodegenerative diseases, ischemic organ injury, dysregulated cell oxidative response, and immune cell function) treatment.
Please note that the findings based on bioinformatic data mining should be better validated by experiments.