Extracellular vesicles (EVs) are common membrane-bound nanovesicles (30–10,000 nm in diameter) that contain diverse biomolecules, such as lipids, proteins, and nucleic acids. EVs are derived from cells through exocytosis, are ingested by target cells, and can transfer biological signals between local or distant cells. Thereby, EVs are widely involved in intercellular communication and, with their ability to promote tissue regeneration, EVs are promising as an alternative to cell therapy compared to transplanted stem cells which cannot evade immune responses. Because of their origin from membranes, EVs can easily cross biological barriers, protect internal carriers from degradation, and participate in the transfer of bioactive components.
These properties determine EV as a potential therapeutic agent in cancer treatment. EVs can be used both in their native form and as vehicles for therapeutic agents as well as vector platforms to construct. EVs secretion is a constitutive phenomenon that is involved in both physiological and pathological processes. Hence, EVs can be exploited as biomarkers, vaccines and drug carriers and can be modified rationally for therapeutic interventions.
We welcome Original Research and Review articles from both academic and industry leaders in Extracellular vesicles field, falling under cancer treatment and diagnosis. Contributions are encouraged in areas including, but not limited to:
1) The development of EVs as a potential source of biomarkers in cancer diagnosis and prognosis. Contributions on this theme are expected to provide clear mechanistic insight into how these markers exert their effects.
2) The mechanism of EVs function in cancer immunity
3) EVs-mediated delivery of anti-tumor agents
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
Extracellular vesicles (EVs) are common membrane-bound nanovesicles (30–10,000 nm in diameter) that contain diverse biomolecules, such as lipids, proteins, and nucleic acids. EVs are derived from cells through exocytosis, are ingested by target cells, and can transfer biological signals between local or distant cells. Thereby, EVs are widely involved in intercellular communication and, with their ability to promote tissue regeneration, EVs are promising as an alternative to cell therapy compared to transplanted stem cells which cannot evade immune responses. Because of their origin from membranes, EVs can easily cross biological barriers, protect internal carriers from degradation, and participate in the transfer of bioactive components.
These properties determine EV as a potential therapeutic agent in cancer treatment. EVs can be used both in their native form and as vehicles for therapeutic agents as well as vector platforms to construct. EVs secretion is a constitutive phenomenon that is involved in both physiological and pathological processes. Hence, EVs can be exploited as biomarkers, vaccines and drug carriers and can be modified rationally for therapeutic interventions.
We welcome Original Research and Review articles from both academic and industry leaders in Extracellular vesicles field, falling under cancer treatment and diagnosis. Contributions are encouraged in areas including, but not limited to:
1) The development of EVs as a potential source of biomarkers in cancer diagnosis and prognosis. Contributions on this theme are expected to provide clear mechanistic insight into how these markers exert their effects.
2) The mechanism of EVs function in cancer immunity
3) EVs-mediated delivery of anti-tumor agents
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
