The tumor microenvironment (TME) is a bidirectional, dynamic, and complex interaction network between tumor cells and mesenchymal cells. In-depth studies of TME are of great significance for elucidating tumor biology and molecular mechanism in the process of tumor genesis and development. However, sometimes the internal balance of TME is not well maintained, resulting in an insufficient or over-activated immune response. Also due to the failure of immune cell homeostasis, some cancer cells remain resistant to common therapies including radiotherapy and chemotherapy, leading to treatment failure.
With the rapid advancements in tumor biology research, minimally invasive interventional therapies such as local ablation, transcatheter arterial chemoembolization, particle implantation, and various types of stent implantation, as well as new systemic therapies such as targeted drug therapy, biological therapy, and immunotherapy, have made enormous strides. These new therapeutic strategies have significantly improved the quality of life and extended the lifespan of patients. More importantly, exploring the underlying molecular mechanisms and biological functions of minimally invasive interventional therapy in tumor immune cell interactions has been widely recognized to improve the therapeutic effects in clinical practices.
This Research Topic aims to explore the impact of minimally invasive interventional therapy on tumor immune microenvironment (TIME) among tumor progression, so as to provide researchers with new insights on novel anti-tumor therapies by targeting the TIME and the related therapeutic drug resistance. We welcome submissions covering but not limited to the following sub-topics:
1. Interventional ablation combined with targeted immunotherapy and immunometabolism to reform the tumor immune microenvironment
2. Development of potential biomarkers that regulate the immunometabolism and immune microenvironment to predict tumor malignant progression
3. Potential role of liquid biopsy as alternative marker for therapeutic response and monitoring
4. Effects of radiofrequency ablation and particle implantation on tumor microenvironment and immune cell homeostasis
5. Novel potential strategies of minimally invasive interventional therapy by targeting TIME in the clinical tumor treatment
6. Exploration of tumor immunophenotypes with clinical and translational value based on TIME
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
The tumor microenvironment (TME) is a bidirectional, dynamic, and complex interaction network between tumor cells and mesenchymal cells. In-depth studies of TME are of great significance for elucidating tumor biology and molecular mechanism in the process of tumor genesis and development. However, sometimes the internal balance of TME is not well maintained, resulting in an insufficient or over-activated immune response. Also due to the failure of immune cell homeostasis, some cancer cells remain resistant to common therapies including radiotherapy and chemotherapy, leading to treatment failure.
With the rapid advancements in tumor biology research, minimally invasive interventional therapies such as local ablation, transcatheter arterial chemoembolization, particle implantation, and various types of stent implantation, as well as new systemic therapies such as targeted drug therapy, biological therapy, and immunotherapy, have made enormous strides. These new therapeutic strategies have significantly improved the quality of life and extended the lifespan of patients. More importantly, exploring the underlying molecular mechanisms and biological functions of minimally invasive interventional therapy in tumor immune cell interactions has been widely recognized to improve the therapeutic effects in clinical practices.
This Research Topic aims to explore the impact of minimally invasive interventional therapy on tumor immune microenvironment (TIME) among tumor progression, so as to provide researchers with new insights on novel anti-tumor therapies by targeting the TIME and the related therapeutic drug resistance. We welcome submissions covering but not limited to the following sub-topics:
1. Interventional ablation combined with targeted immunotherapy and immunometabolism to reform the tumor immune microenvironment
2. Development of potential biomarkers that regulate the immunometabolism and immune microenvironment to predict tumor malignant progression
3. Potential role of liquid biopsy as alternative marker for therapeutic response and monitoring
4. Effects of radiofrequency ablation and particle implantation on tumor microenvironment and immune cell homeostasis
5. Novel potential strategies of minimally invasive interventional therapy by targeting TIME in the clinical tumor treatment
6. Exploration of tumor immunophenotypes with clinical and translational value based on TIME
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.