Recent advances in the field of metabolism and inflammation have shown a relationship between disturbed metabolism and chronic inflammation. Because of these observations, the term metaflammation, which describes inflammation caused by metabolic anomalies, has rightly become the phrase of our times. Even before metaflammation was coined, contribution of metabolism towards immune responses was captured in the term immunometabolism especially in the context of cancer research. As an organ that is constantly in exchange with the environment, the lung is exposed not only to the environmental factors such as viral and non-viral pathogens and allergens, but also to organism’s specific factors, e.g., nutrition and metabolism, which are all capable of inducing or triggering inflammatory responses. Interestingly, the interplay between metabolism and inflammation is not only important in adults, but already determines intrauterine as well as early postnatal the risk for lung disease. However, the molecular and cellular responses as well as pathological impacts resulting from metabolic conditions, infections and allergy have been shown to differ depending on specific immune cell types and underlying metabolic conditions such as obesity.
As much as it is known that the processes of cellular growth causes bioenergetic changes which leads to intracellular metabolic reprograming such as mitochondrial re-organization from catabolism to anabolic processes, how these metabolic changes impact innate immune cells such as macrophages, dendritic cells, epithelial cells and innate lymphoid cells in the lung is only partly elucidated. Thus, with this article collection we aim to understand how metabolic conditions regulate and determine inflammation at cellular and systemic level and how this influences pulmonary integrity as well as lung disease development and progression.
We welcome the submission of the following article types to this Research Topic: Original Research, Review and Mini-Review. This Research Topic aims to summarize recent developments in the field, focusing on, but not limited to:
• How metabolic conditions regulate and determine inflammation at cellular and systemic level;
• How metabolic condition influences pulmonary integrity as well as lung disease development and progression;
• Impact of metabolism and inflammatory processes on both adaptive and innate pulmonary immune cells;
• How metabolism and inflammatory processes affects the pathogenesis of neonatal and adult lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung fibrosis and infections.
Recent advances in the field of metabolism and inflammation have shown a relationship between disturbed metabolism and chronic inflammation. Because of these observations, the term metaflammation, which describes inflammation caused by metabolic anomalies, has rightly become the phrase of our times. Even before metaflammation was coined, contribution of metabolism towards immune responses was captured in the term immunometabolism especially in the context of cancer research. As an organ that is constantly in exchange with the environment, the lung is exposed not only to the environmental factors such as viral and non-viral pathogens and allergens, but also to organism’s specific factors, e.g., nutrition and metabolism, which are all capable of inducing or triggering inflammatory responses. Interestingly, the interplay between metabolism and inflammation is not only important in adults, but already determines intrauterine as well as early postnatal the risk for lung disease. However, the molecular and cellular responses as well as pathological impacts resulting from metabolic conditions, infections and allergy have been shown to differ depending on specific immune cell types and underlying metabolic conditions such as obesity.
As much as it is known that the processes of cellular growth causes bioenergetic changes which leads to intracellular metabolic reprograming such as mitochondrial re-organization from catabolism to anabolic processes, how these metabolic changes impact innate immune cells such as macrophages, dendritic cells, epithelial cells and innate lymphoid cells in the lung is only partly elucidated. Thus, with this article collection we aim to understand how metabolic conditions regulate and determine inflammation at cellular and systemic level and how this influences pulmonary integrity as well as lung disease development and progression.
We welcome the submission of the following article types to this Research Topic: Original Research, Review and Mini-Review. This Research Topic aims to summarize recent developments in the field, focusing on, but not limited to:
• How metabolic conditions regulate and determine inflammation at cellular and systemic level;
• How metabolic condition influences pulmonary integrity as well as lung disease development and progression;
• Impact of metabolism and inflammatory processes on both adaptive and innate pulmonary immune cells;
• How metabolism and inflammatory processes affects the pathogenesis of neonatal and adult lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung fibrosis and infections.