The skin is the largest organ in the body and is continually exposed to external stimuli, such as chemical and environmental substances, and internal stimuli, such as drugs and substances that we consume orally. Skin toxicity can be categorized according to the mechanism of onset into: contact dermatitis, photosensitivity, contact urticaria, chemical-induced acne, pigmentation disorder and drug-induced and tumor-induced rash. Furthermore, it can also be classified according to the route of exposure, i.e. due to systemic effects or local skin irritation (local toxicity). Over the years, many studies have focused on the analysis of cutaneous toxicity induced by different substances. However, the continuous introduction of new pharmaceuticals, personal care products (i.e. detergents, dental hygiene products, disinfectants, cosmetics) and other products (i.e. household cleaning products, tattoo components) onto the market, combined with the continuous evolution of our habits and environmental change, always requires new studies and insights.
This Research Topic will take a deep dive into how our habits can influence cutaneous toxicity by looking at the impact of lesser studied substances on skin toxicity. In particular, this topic aims to collect all those studies based on new approach methodologies (NAMs). Over the past few years, NAMs are increasingly being used for regulatory decision making by agencies around the world due to their potential to produce reliably and efficiently results, by reducing the use of animals.
For this Research Topic, we welcome submissions of original research, reviews, mini-reviews, methods, and brief research reports focusing on, but not limited to, the following themes:
• Pharmaceutical and personal care products and their potential toxic effects on skin
• The effect of components of tattoo ink on the skin
• Drug-induced cutaneous toxicity
• Environmental contaminants and skin toxicity
• How the increased use of disinfectants (e.g. as a result of the COVID-19 pandemic) have changed skin sensitization
The skin is the largest organ in the body and is continually exposed to external stimuli, such as chemical and environmental substances, and internal stimuli, such as drugs and substances that we consume orally. Skin toxicity can be categorized according to the mechanism of onset into: contact dermatitis, photosensitivity, contact urticaria, chemical-induced acne, pigmentation disorder and drug-induced and tumor-induced rash. Furthermore, it can also be classified according to the route of exposure, i.e. due to systemic effects or local skin irritation (local toxicity). Over the years, many studies have focused on the analysis of cutaneous toxicity induced by different substances. However, the continuous introduction of new pharmaceuticals, personal care products (i.e. detergents, dental hygiene products, disinfectants, cosmetics) and other products (i.e. household cleaning products, tattoo components) onto the market, combined with the continuous evolution of our habits and environmental change, always requires new studies and insights.
This Research Topic will take a deep dive into how our habits can influence cutaneous toxicity by looking at the impact of lesser studied substances on skin toxicity. In particular, this topic aims to collect all those studies based on new approach methodologies (NAMs). Over the past few years, NAMs are increasingly being used for regulatory decision making by agencies around the world due to their potential to produce reliably and efficiently results, by reducing the use of animals.
For this Research Topic, we welcome submissions of original research, reviews, mini-reviews, methods, and brief research reports focusing on, but not limited to, the following themes:
• Pharmaceutical and personal care products and their potential toxic effects on skin
• The effect of components of tattoo ink on the skin
• Drug-induced cutaneous toxicity
• Environmental contaminants and skin toxicity
• How the increased use of disinfectants (e.g. as a result of the COVID-19 pandemic) have changed skin sensitization
