Solid organ transplantation is a life-saving treatment for patients with advanced heart, lung, kidney, liver, and lung disease. Outcomes after transplantation have improved over the past 20 years with improvements in donor selection, surgical techniques, and advancements in immunosuppression. However, antibody-mediated rejection remains a vexing problem that frequently results in allograft failure.
This research topic will review the current understanding and latest advances in antibody-mediated rejection across all solid organ transplants. These will span the spectrum from a better understanding of the immunology and pathogenesis, to improved diagnostics, treatments, ongoing gaps in knowledge, and future research.
Topics covered within this collection include immunology and pathogenesis, HLA antibodies, non-HLA antibodies, pre-transplant allosensitization, pathology, diagnostics, treatment, outcomes, and future research. Manuscripts may include original scientific manuscripts and review articles. Ideally, manuscripts would discuss themes relevant to all solid organ transplants but may focus on a specific organ where recent advances have been made. This may serve as a roadmap for other organs to follow in future research.
Solid organ transplantation is a life-saving treatment for patients with advanced heart, lung, kidney, liver, and lung disease. Outcomes after transplantation have improved over the past 20 years with improvements in donor selection, surgical techniques, and advancements in immunosuppression. However, antibody-mediated rejection remains a vexing problem that frequently results in allograft failure.
This research topic will review the current understanding and latest advances in antibody-mediated rejection across all solid organ transplants. These will span the spectrum from a better understanding of the immunology and pathogenesis, to improved diagnostics, treatments, ongoing gaps in knowledge, and future research.
Topics covered within this collection include immunology and pathogenesis, HLA antibodies, non-HLA antibodies, pre-transplant allosensitization, pathology, diagnostics, treatment, outcomes, and future research. Manuscripts may include original scientific manuscripts and review articles. Ideally, manuscripts would discuss themes relevant to all solid organ transplants but may focus on a specific organ where recent advances have been made. This may serve as a roadmap for other organs to follow in future research.