Metal elements play an essential role in regulating cell activity, serving as co-factors for a wide range of proteins and constituents of many hormones and vitamins necessary for correct physiological function; metal ions underpin numerous biological processes ranging from metabolism to cell proliferation. A reduced intake or abnormal metabolic process of some metal elements may contribute to the occurrence and development of various diseases, including tumors, cardiovascular diseases and neurodegenerative diseases.
An iron-dependent process of cell death, ferroptosis, was discovered in recent years and is characterized by excessive lipid peroxidation and reactive oxygen species accumulations. Metal element accumulation in the brain and neural tissues has been linked to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and other diseases. It has been found in previous studies that induced or inhibited metal element-mediated metabolic processes can delay and prevent diseases, which means this strategy of regulating metal ions could serve as a treatment target for diseases like neurodegeneration. For example, there have been a number of clinical trials for the use of chelating drugs in the treatment of neurodegenerative diseases.
Our understanding of how metal element homeostasis contributes to normal physiology and how imbalances affect the development of disease is underdeveloped, raising the possibility of new therapeutic targets and diagnostic tools for treating diseases. In this Research Topic, we hope to attract 1. research into the consequences of metal element imbalance in neurodegenerative diseases, including ferroptosis and cuproptosis. 2. investigation into the biological functions and clinical value of metal elements in diagnosing, preventing, and treating neurodegenerative diseases using chemical, material, biological or clinical data.
Original Research articles, Brief Research Reports, and Reviews (systematic reviews and meta-analyses) are all welcome. The subtopics of this Research Topic include, but are not limited to, the following:
• Mechanisms by which metal ions contribute to neurodegenerative disease states. (such as how cell signaling pathways interact with metal elements or how metal ions are involved in regulating cell proliferation and other cellular activities);
• Clinical value of targeting metal elements in the diagnosis, prevention, and treatment of neurodegenerative diseases;
• The link between metal elements and other neurologic diseases, including neurological cancer and stroke.
We would like to thank Dr. Bingjie Li, the First Affiliated Hospital of Zhengzhou University, for serving as the Topic Coordinator and contributing to preparing the proposal for this Research Topic.
Metal elements play an essential role in regulating cell activity, serving as co-factors for a wide range of proteins and constituents of many hormones and vitamins necessary for correct physiological function; metal ions underpin numerous biological processes ranging from metabolism to cell proliferation. A reduced intake or abnormal metabolic process of some metal elements may contribute to the occurrence and development of various diseases, including tumors, cardiovascular diseases and neurodegenerative diseases.
An iron-dependent process of cell death, ferroptosis, was discovered in recent years and is characterized by excessive lipid peroxidation and reactive oxygen species accumulations. Metal element accumulation in the brain and neural tissues has been linked to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and other diseases. It has been found in previous studies that induced or inhibited metal element-mediated metabolic processes can delay and prevent diseases, which means this strategy of regulating metal ions could serve as a treatment target for diseases like neurodegeneration. For example, there have been a number of clinical trials for the use of chelating drugs in the treatment of neurodegenerative diseases.
Our understanding of how metal element homeostasis contributes to normal physiology and how imbalances affect the development of disease is underdeveloped, raising the possibility of new therapeutic targets and diagnostic tools for treating diseases. In this Research Topic, we hope to attract 1. research into the consequences of metal element imbalance in neurodegenerative diseases, including ferroptosis and cuproptosis. 2. investigation into the biological functions and clinical value of metal elements in diagnosing, preventing, and treating neurodegenerative diseases using chemical, material, biological or clinical data.
Original Research articles, Brief Research Reports, and Reviews (systematic reviews and meta-analyses) are all welcome. The subtopics of this Research Topic include, but are not limited to, the following:
• Mechanisms by which metal ions contribute to neurodegenerative disease states. (such as how cell signaling pathways interact with metal elements or how metal ions are involved in regulating cell proliferation and other cellular activities);
• Clinical value of targeting metal elements in the diagnosis, prevention, and treatment of neurodegenerative diseases;
• The link between metal elements and other neurologic diseases, including neurological cancer and stroke.
We would like to thank Dr. Bingjie Li, the First Affiliated Hospital of Zhengzhou University, for serving as the Topic Coordinator and contributing to preparing the proposal for this Research Topic.
