The microbiome has been implicated in asthma pathogenesis, particularly during early life exposures. Disturbances in microbiome composition and metabolism, both in the gut and the lungs, contributes to immune dysfunction underlying the development and severity of asthma.
However, translating these associations into clinical outcomes has proven difficult and will require further understanding the relationship between the microbiome, asthma and factors influencing this relationship, both host-derived and external. This research topic will aim to explore the interplay of genetics, diet, medications, disease phenotype or severity, environmental exposures, and other factors with host-microbiome interactions in asthma. In particular, articles which go beyond associative studies to explore cause-effect relationships are strongly encouraged.
Suitable themes for manuscripts include, but are not limited to:
• The early life microbiome, immune responses and asthma development
• Asthma prevention through early microbial interventions
• Environmental and occupational impacts of the microbiome in asthma
• Infections, pathogens in the microbiome and asthma outcomes
• Nutrition and the microbiome in asthma
• Microbiota associations with inflammatory pathways in asthma, including host genetic factors involved
• The role of the microbiome in asthma phenotypes and severity
• The influence of genetics on host-microbiome interactions in asthma
• Therapeutic manipulation of the microbiome for established asthma
• Interactions between asthma medications and the microbiome
• Long term implications of antibiotic medications on the microbiome
• Mechanism of action of macrolides in asthma - are beneficial effects mediated via lung/ gut microbiome?
• Mechanisms of action of probiotics in asthma
• The contribution of microbiota dysbiosis to asthma pathogenesis and heterogeneity in asthma phenotypes-endotypes and administered medication
• Mechanisms between the gut-lung dysbiosis and respiratory diseases pathogenesis
• Implications of the microbiome for asthma in the elderly
All article types accepted by Frontiers in Allergy are welcome.
The microbiome has been implicated in asthma pathogenesis, particularly during early life exposures. Disturbances in microbiome composition and metabolism, both in the gut and the lungs, contributes to immune dysfunction underlying the development and severity of asthma.
However, translating these associations into clinical outcomes has proven difficult and will require further understanding the relationship between the microbiome, asthma and factors influencing this relationship, both host-derived and external. This research topic will aim to explore the interplay of genetics, diet, medications, disease phenotype or severity, environmental exposures, and other factors with host-microbiome interactions in asthma. In particular, articles which go beyond associative studies to explore cause-effect relationships are strongly encouraged.
Suitable themes for manuscripts include, but are not limited to:
• The early life microbiome, immune responses and asthma development
• Asthma prevention through early microbial interventions
• Environmental and occupational impacts of the microbiome in asthma
• Infections, pathogens in the microbiome and asthma outcomes
• Nutrition and the microbiome in asthma
• Microbiota associations with inflammatory pathways in asthma, including host genetic factors involved
• The role of the microbiome in asthma phenotypes and severity
• The influence of genetics on host-microbiome interactions in asthma
• Therapeutic manipulation of the microbiome for established asthma
• Interactions between asthma medications and the microbiome
• Long term implications of antibiotic medications on the microbiome
• Mechanism of action of macrolides in asthma - are beneficial effects mediated via lung/ gut microbiome?
• Mechanisms of action of probiotics in asthma
• The contribution of microbiota dysbiosis to asthma pathogenesis and heterogeneity in asthma phenotypes-endotypes and administered medication
• Mechanisms between the gut-lung dysbiosis and respiratory diseases pathogenesis
• Implications of the microbiome for asthma in the elderly
All article types accepted by Frontiers in Allergy are welcome.