About this Research Topic
Damage-associated molecular patterns (DAMPs) refer to endogenous molecules released from damaged or dying cells in response to trauma or infection by a pathogen, which could bind to pattern recognition receptors (PRRs) and activate the immune response. In the absence of injury or infection, DAMPs, such as HMGB1, histones, S100 proteins, and heat shock proteins have distinct intracellular and extracellular roles. Intracellular DAMPs play a role in regulating DNA transcription, maintaining calcium homeostasis, cell proliferation and differentiation, while extracellular DAMPs are associated with autoimmune states and the severity of inflammatory disorders, such as sepsis, craniocerebral injury, acute lung injury, or inflammatory bowel disease.
In recent years, the role of DAMPs in pathogen infection has attracted much attention. On the one hand, it can remove pathogens and infected/damaged cells. On the other hand, it can aggravate tissue damage caused by inflammation, increase the susceptibility of pathogens, and further aggravate the extent of infection. As endogenous molecules promoting inflammatory response, DAMPs are involved in the pathophysiological processes of infection with pathogens including viruses, bacteria, fungi and parasites. Extensive crosstalk between immune responses elicited by DAMPs and Pathogen-associated molecular patterns (PAMPs) during injury or infections has been reported over the years. However, the mechanistic details of DAMPs in infection, especially in bone infection, are largely unknown.
This research topic focuses on the role of DAMPs in infectious diseases and the potential molecular mechanism. In addition, we aim to further investigate the intracellular and extracellular roles of DAMPs, thus providing new theoretical basis and therapeutic targets for the prevention, diagnosis and treatment of infection-related diseases.We welcome authors to submit Review and Original research articles focusing on, but not limited to, the following subtopics:
1.DAMPs signaling pathways, including novel sensors, activation mechanisms, and effector molecules.
2.New functions and mechanisms of DAMPs in infection-related diseases.
3.Interactions between DAMPs molecules.
4.Intracellular and extracellular effects of DAMPs.
5.New therapies targeting DAMPs for infectious disease
In recent years, the role of DAMPs in pathogen infection has attracted much attention. On the one hand, it can remove pathogens and infected/damaged cells. On the other hand, it can aggravate tissue damage caused by inflammation, increase the susceptibility of pathogens, and further aggravate the extent of infection. As endogenous molecules promoting inflammatory response, DAMPs are involved in the pathophysiological processes of infection with pathogens including viruses, bacteria, fungi and parasites. Extensive crosstalk between immune responses elicited by DAMPs and Pathogen-associated molecular patterns (PAMPs) during injury or infections has been reported over the years. However, the mechanistic details of DAMPs in infection, especially in bone infection, are largely unknown.
This research topic focuses on the role of DAMPs in infectious diseases and the potential molecular mechanism. In addition, we aim to further investigate the intracellular and extracellular roles of DAMPs, thus providing new theoretical basis and therapeutic targets for the prevention, diagnosis and treatment of infection-related diseases.We welcome authors to submit Review and Original research articles focusing on, but not limited to, the following subtopics:
1.DAMPs signaling pathways, including novel sensors, activation mechanisms, and effector molecules.
2.New functions and mechanisms of DAMPs in infection-related diseases.
3.Interactions between DAMPs molecules.
4.Intracellular and extracellular effects of DAMPs.
5.New therapies targeting DAMPs for infectious disease
Keywords: Immunity, DAMPs, Infection, Mechanism, Therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
