About this Research Topic
Arboviruses, i.e., viruses transmitted by the arthropod vector, have complex transmission cycles between the vertebrates and the vectors. Emerging arboviruses Infection, including dengue, Zika, and chikungunya, have similar epidemiology, transmission cycles, and clinical symptoms at onset, which are all transmitted by mosquitoes, causing millions of human and animal infection per year. Consequently, it is imperative to improve our understanding of the interactions between the biological and critical environmental factors in the pathogenesis, disease outcomes, and transmission of arboviruses infection.
As we all know, Aedes spp. mosquitoes are the primary vectors for arboviruses and have become one of the most invasive animals in the world. Confusingly, the genomes of Aedes spp. mosquitoes harbor some segments and locus of non-retroviral RNA viruses (nrEVEs). The potential biological role of the nrEVEs occurrences in arboviral infection and the mechanism of nrEVEs integration remain unclear and vague.
In this Research Topic, we focus specifically on mosquito-borne arboviruses and explore the potential biological and environmental factors that have important implications for arbovirus infection and transmission. Besides, we are also interested in the mechanism of the interaction between nrEVEs integration in mosquito genomes and the arboviral infection, which can potentially help to identify novel targets for intervention and therapeutics.
In general, the goal of this Research Topic is to focus on mosquito-borne arboviruses and nrEVEs integrations in mosquito genomes, to reveal the important roles of the biological and environmental factors in pathogenesis, disease outcomes, and transmission of arboviruses infection and helps us to discover novel targets for intervention and therapeutics
Specifically, we would like:
1) to identify dominated pathways and specific genes during the arbovirus infection process in mosquitoes
2) to explore the effect of vector genetics on arborvirus susceptibility in various mosquito populations and discuss the influence of selection during mosquito colonization on vector competence
3) to demonstrate the relationship between the arbovirus infection and the non-retroviral RNA viruses (nrEVEs) integrations in mosquito genome
4) to develop new transmission-blocking strategies for the control of mosquito-borne arboviruses
As we all know, Aedes spp. mosquitoes are the primary vectors for arboviruses and have become one of the most invasive animals in the world. Confusingly, the genomes of Aedes spp. mosquitoes harbor some segments and locus of non-retroviral RNA viruses (nrEVEs). The potential biological role of the nrEVEs occurrences in arboviral infection and the mechanism of nrEVEs integration remain unclear and vague.
In this Research Topic, we focus specifically on mosquito-borne arboviruses and explore the potential biological and environmental factors that have important implications for arbovirus infection and transmission. Besides, we are also interested in the mechanism of the interaction between nrEVEs integration in mosquito genomes and the arboviral infection, which can potentially help to identify novel targets for intervention and therapeutics.
In general, the goal of this Research Topic is to focus on mosquito-borne arboviruses and nrEVEs integrations in mosquito genomes, to reveal the important roles of the biological and environmental factors in pathogenesis, disease outcomes, and transmission of arboviruses infection and helps us to discover novel targets for intervention and therapeutics
Specifically, we would like:
1) to identify dominated pathways and specific genes during the arbovirus infection process in mosquitoes
2) to explore the effect of vector genetics on arborvirus susceptibility in various mosquito populations and discuss the influence of selection during mosquito colonization on vector competence
3) to demonstrate the relationship between the arbovirus infection and the non-retroviral RNA viruses (nrEVEs) integrations in mosquito genome
4) to develop new transmission-blocking strategies for the control of mosquito-borne arboviruses
Keywords: mosquito, arbovirus, vector competence, nrEVEs
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