Infectious diseases have always been a significant challenge to global public health, and the pandemic caused by the novel coronavirus (SARS-CoV2) has once again sounded the alarm. Bacteria are one of the most important pathogens of infectious diseases. Although antibiotics can effectively control most bacterial infections, the emergence of multi-drug-resistant and pan-drug-resistant strains in recent years may bring humans back to the pre-antibiotic era. One of the most effective strategies to address this daunting challenge is to acquire new anti-microbial tools. A host-directed therapy that augments host defense or modulates excessive inflammation, or both, catches the attention of researchers. It does not cause lethal pressure on bacteria and thus has a low probability of inducing resistance.
Innate immunity and adaptive immunity compose the main immune strategies in vertebrates. The innate immune system is an older evolutionary defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms, independent of antigen presentation. Using this powerful weapon, the host cells protect themselves from the evasion of various microbes, especially intracellular bacteria and viruses. However, pathogenic bacteria have acquired virulent factors that can effectively escape the innate immune system, due to the long-term interaction with the host. Therefore, studying the interaction between microbes and the hosts can reveal the pathogen recognition mechanism that is almost impossible to obtain under normal conditions.
This Research Topic seeks Original Research papers as well as Review articles that will help to improve our knowledge of novel mechanisms of innate immunity against intracellular bacteria. In addition, new findings of bacterial effectors regulating host innate immunity would also be welcome. Ultimately, we welcome any studies that disclose novel and important targets and processes involved in innate immunity that might be used for translational research in infectious diseases. Subtopics include but are not limited to:
• Fundamental research regarding the mechanisms of innate immunity in fighting against intracellular bacterial infection.
• Discovery of the relationship between bacterial effectors and innate immunity.
• Clinical Research regarding the treatment or prevention of intracellular bacteria-related diseases.
• Novel strategies based on innate immunity regulation in preventing bacterial infections.
• Bioinformatics analyzing the key regulators in oxidative stress and cell death.
Infectious diseases have always been a significant challenge to global public health, and the pandemic caused by the novel coronavirus (SARS-CoV2) has once again sounded the alarm. Bacteria are one of the most important pathogens of infectious diseases. Although antibiotics can effectively control most bacterial infections, the emergence of multi-drug-resistant and pan-drug-resistant strains in recent years may bring humans back to the pre-antibiotic era. One of the most effective strategies to address this daunting challenge is to acquire new anti-microbial tools. A host-directed therapy that augments host defense or modulates excessive inflammation, or both, catches the attention of researchers. It does not cause lethal pressure on bacteria and thus has a low probability of inducing resistance.
Innate immunity and adaptive immunity compose the main immune strategies in vertebrates. The innate immune system is an older evolutionary defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms, independent of antigen presentation. Using this powerful weapon, the host cells protect themselves from the evasion of various microbes, especially intracellular bacteria and viruses. However, pathogenic bacteria have acquired virulent factors that can effectively escape the innate immune system, due to the long-term interaction with the host. Therefore, studying the interaction between microbes and the hosts can reveal the pathogen recognition mechanism that is almost impossible to obtain under normal conditions.
This Research Topic seeks Original Research papers as well as Review articles that will help to improve our knowledge of novel mechanisms of innate immunity against intracellular bacteria. In addition, new findings of bacterial effectors regulating host innate immunity would also be welcome. Ultimately, we welcome any studies that disclose novel and important targets and processes involved in innate immunity that might be used for translational research in infectious diseases. Subtopics include but are not limited to:
• Fundamental research regarding the mechanisms of innate immunity in fighting against intracellular bacterial infection.
• Discovery of the relationship between bacterial effectors and innate immunity.
• Clinical Research regarding the treatment or prevention of intracellular bacteria-related diseases.
• Novel strategies based on innate immunity regulation in preventing bacterial infections.
• Bioinformatics analyzing the key regulators in oxidative stress and cell death.