The past decade has witnessed progress in etiological studies which have impacted on our knowledge of the overlap of neurodevelopmental disorders and psychiatric problems thanks in part to the use of multiple cutting-edge research strategies. This has progressed the hypothesis that a neurodevelopmental trajectory may be shared by these two conditions which is directed by both genetic variants and environmental stress often working synergistically. This can lead to transient and stable changes in CNS development including organization of neural networks which co-segregates with neurodevelopmental and psychiatric disorders in which there are a plethora of questions yet to be addressed. Despite the substantial inheritable common variants identified by large-scale molecular epidemiologic studies there is now an appreciation of the growing roles of rare genetic mutation, de novo mutation, tandem repeats and retrotransposon elements which profoundly affect the genome integrity and stability underpinning many of the changes observed.
In this Research Topic, we would like to attract submissions which describe the new advances in the molecular pathways or novel neural networks underpinning neurodevelopmental and psychiatric disorders. An interplay between neurodevelopment and mental health is preferred but not essential. We encourage a wide range of submissions including original articles, review papers, innovative research methods and case reports. Specifically, we aim to address the following topics (but not limited to):
- Identify novel molecules and associated signaling cascades which may reshape neural development.
- Determine key neural circuits and plasticity responsible for normal brain functions using state-of-art research methods including but not solely optogenetics, DREADD, multi-omics approaches.
- Address the converged pathways shared by neurodevelopmental and psychiatric problems and neural plasticity changes which may also be important for common neurodegenerative diseases such as Parkinson's, Alzheimer's diseases or cerebral ischemia.
- Reveal negative perinatal stress and related mechanisms which may alter brain developmental progress and neural circuit formation.
- Neural circuits or pathway responsible for psychiatric deceases evolutionally conserved between species, such as depression observed in some primates.
- Explore gene x environment interactions that modify our neurochemistry CNS & periphery signaling.
- Translation from model organisms to human health.
- Living with and modulation of aberrant neurodevelopmental changes.
The past decade has witnessed progress in etiological studies which have impacted on our knowledge of the overlap of neurodevelopmental disorders and psychiatric problems thanks in part to the use of multiple cutting-edge research strategies. This has progressed the hypothesis that a neurodevelopmental trajectory may be shared by these two conditions which is directed by both genetic variants and environmental stress often working synergistically. This can lead to transient and stable changes in CNS development including organization of neural networks which co-segregates with neurodevelopmental and psychiatric disorders in which there are a plethora of questions yet to be addressed. Despite the substantial inheritable common variants identified by large-scale molecular epidemiologic studies there is now an appreciation of the growing roles of rare genetic mutation, de novo mutation, tandem repeats and retrotransposon elements which profoundly affect the genome integrity and stability underpinning many of the changes observed.
In this Research Topic, we would like to attract submissions which describe the new advances in the molecular pathways or novel neural networks underpinning neurodevelopmental and psychiatric disorders. An interplay between neurodevelopment and mental health is preferred but not essential. We encourage a wide range of submissions including original articles, review papers, innovative research methods and case reports. Specifically, we aim to address the following topics (but not limited to):
- Identify novel molecules and associated signaling cascades which may reshape neural development.
- Determine key neural circuits and plasticity responsible for normal brain functions using state-of-art research methods including but not solely optogenetics, DREADD, multi-omics approaches.
- Address the converged pathways shared by neurodevelopmental and psychiatric problems and neural plasticity changes which may also be important for common neurodegenerative diseases such as Parkinson's, Alzheimer's diseases or cerebral ischemia.
- Reveal negative perinatal stress and related mechanisms which may alter brain developmental progress and neural circuit formation.
- Neural circuits or pathway responsible for psychiatric deceases evolutionally conserved between species, such as depression observed in some primates.
- Explore gene x environment interactions that modify our neurochemistry CNS & periphery signaling.
- Translation from model organisms to human health.
- Living with and modulation of aberrant neurodevelopmental changes.
