Around 100 trillion microbes reside in the human body and shape a network of complex ecosystems. They have a vital role in maintaining host health, and the imbalance of microbiota is associated with various human diseases. The oral and other body sites, including skin, genital tract, intestinal tract and respiratory tract, have close connection physiologically. The influence of oral microbes on the microbiota of other sites is increasingly recognized.
The oral cavity has been considered a vital body niche to inhabit plenty of microbes. Therefore, more and more scholars have been aware of the importance and role of the oral microbiome in human health. Studies have shown that the disorder of the oral microbiome might affect other site microbiomes and is associated with a variety of human diseases, including gastrointestinal system diseases like inflammatory bowel disease, liver cirrhosis, pancreatic cancer, nervous system diseases like Alzheimer’s disease, endocrine system diseases like diabetes, adverse pregnancy outcomes, obesity and polycystic ovary syndrome.
However, many issues remain to be resolved. The ecological processes and individual heterogeneity of oral microbes affecting microbiota at other sites remain unclear due to the lack of sufficient samples and studies. Thus, it is necessary to mine data, accumulate clinical samples, and explore the relationship between oral microbiomes and microbiomes at other sites. At the same time, the relationship between clinical phenotype and microbiota, whether the change of microbiota could be applied to predict the risk of human diseases, whether new technical methods provide a further understanding of the human microbiome, and the longitudinal follow-up study of human microbiome relationship are also hot spots in clinical research.
We encourage researchers to submit both original research and review articles exploring the relationship and impact factors of the microbiomes of the oral cavity and other body sites for both research and clinical applications. Potential topics include but are not limited to:
• Oral microbiome and its correlation with the microbiome from other sites in terms of growth and development.
• Oral microbiome dysbiosis associated with human diseases in other sites
• Oral diseases and other sites of microbiome dysbiosis
• Ectopic colonization
• The clinical diagnosis and treatment of microbiota pathogenic factors associated with human diseases
Around 100 trillion microbes reside in the human body and shape a network of complex ecosystems. They have a vital role in maintaining host health, and the imbalance of microbiota is associated with various human diseases. The oral and other body sites, including skin, genital tract, intestinal tract and respiratory tract, have close connection physiologically. The influence of oral microbes on the microbiota of other sites is increasingly recognized.
The oral cavity has been considered a vital body niche to inhabit plenty of microbes. Therefore, more and more scholars have been aware of the importance and role of the oral microbiome in human health. Studies have shown that the disorder of the oral microbiome might affect other site microbiomes and is associated with a variety of human diseases, including gastrointestinal system diseases like inflammatory bowel disease, liver cirrhosis, pancreatic cancer, nervous system diseases like Alzheimer’s disease, endocrine system diseases like diabetes, adverse pregnancy outcomes, obesity and polycystic ovary syndrome.
However, many issues remain to be resolved. The ecological processes and individual heterogeneity of oral microbes affecting microbiota at other sites remain unclear due to the lack of sufficient samples and studies. Thus, it is necessary to mine data, accumulate clinical samples, and explore the relationship between oral microbiomes and microbiomes at other sites. At the same time, the relationship between clinical phenotype and microbiota, whether the change of microbiota could be applied to predict the risk of human diseases, whether new technical methods provide a further understanding of the human microbiome, and the longitudinal follow-up study of human microbiome relationship are also hot spots in clinical research.
We encourage researchers to submit both original research and review articles exploring the relationship and impact factors of the microbiomes of the oral cavity and other body sites for both research and clinical applications. Potential topics include but are not limited to:
• Oral microbiome and its correlation with the microbiome from other sites in terms of growth and development.
• Oral microbiome dysbiosis associated with human diseases in other sites
• Oral diseases and other sites of microbiome dysbiosis
• Ectopic colonization
• The clinical diagnosis and treatment of microbiota pathogenic factors associated with human diseases
