Pathological neuroinflammation of the central nervous system (CNS) is a hallmark of many disease conditions. Neuropathic pain, neurodegenerative disorders, glioblastoma, drug abuse, and traumatic brain injury are all characterized by the chronic activation of microglia, resulting in neuroinflammation. Neuroinflammation is linked to the onset and progress of neurodegenerative disorders (e.g. Alzheimer’s disease, Parkinson’s disease) and autoimmune pathologies (e.g. multiple sclerosis). Over the last several years, novel cascades have been recognized as essential contributors to the development of neuroinflammation, and multiple targets have been identified for drug development.
The aim of this article collection is to assemble studies that represent the current landscape of strategies to treat neuroinflammation in the central nervous system. Our goal is to have a broad scope of studies presented from drug development, pharmacology, and cell biology perspectives.
In this Research Topic, we invite researchers from both academia and industrial perspectives to submit recent updates as original research and review articles on the following, but not limited to, topics:
- The development of novel targets to target cellular senescence-related pathways,
- Success in developing small molecules of interest or immunotherapeutic agents to address the pathological neuroinflammation in the central nervous system.
- Current state of anti-inflammatory strategies.
Pathological neuroinflammation of the central nervous system (CNS) is a hallmark of many disease conditions. Neuropathic pain, neurodegenerative disorders, glioblastoma, drug abuse, and traumatic brain injury are all characterized by the chronic activation of microglia, resulting in neuroinflammation. Neuroinflammation is linked to the onset and progress of neurodegenerative disorders (e.g. Alzheimer’s disease, Parkinson’s disease) and autoimmune pathologies (e.g. multiple sclerosis). Over the last several years, novel cascades have been recognized as essential contributors to the development of neuroinflammation, and multiple targets have been identified for drug development.
The aim of this article collection is to assemble studies that represent the current landscape of strategies to treat neuroinflammation in the central nervous system. Our goal is to have a broad scope of studies presented from drug development, pharmacology, and cell biology perspectives.
In this Research Topic, we invite researchers from both academia and industrial perspectives to submit recent updates as original research and review articles on the following, but not limited to, topics:
- The development of novel targets to target cellular senescence-related pathways,
- Success in developing small molecules of interest or immunotherapeutic agents to address the pathological neuroinflammation in the central nervous system.
- Current state of anti-inflammatory strategies.
