Current and Future Trends in Gestational Diabetes Diagnosis, Care and Neonatal Outcomes

Cover image for research topic "Current and Future Trends in Gestational Diabetes Diagnosis, Care and Neonatal Outcomes"
54.5K
views
110
authors
15
articles
Editors
4
Impact
Loading...
2,098 views
7 citations
4,106 views
7 citations
Demonstrates the inclusion and exclusion criteria of our study population; glycated hemoglobin A1c (HbA1c); gestational diabetes mellitus (GDM); fasting plasma glucose (FPG); 2hPG (2-hour plasma glucose); Oral glucose tolerance test (OGTT); chronic diseases (hypertension, liver, kidney, heart, lung and other major organ diseases, or tumors); autoimmune diseases (Sjogren's syndrome, anticardiolipin syndrome, myasthenia gravis).
Original Research
16 March 2023
The association between maternal HbA1c and adverse outcomes in gestational diabetes
Marie Parfaite Uwimana Muhuza
4 more and 
Zhaoxia Liang

Background: The role of HbA1c in women with gestational diabetes mellitus (GDM) is still unclear, particularly in the Asian population.

Aim: To investigate the association between HbA1c levels and adverse outcomes considering maternal age, pre-pregnancy body mass index (BMI), and gestational weight gain (GWG) in women with GDM.

Method: A retrospective study included 2048 women with GDM and singleton live births. Using logistic regression, the associations between HbA1c and adverse pregnancy outcomes were assessed.

Result: Compared to women with HbA1c ≤ 5.0%, HbA1c was significantly associated with macrosomia (aOR 2.63,95%CI1.61,4.31), pregnancy-induced hypertension (PIH, aOR 2.56,95%CI1.57,4.19), preterm birth (aOR 1.64,95%CI 1.05,2.55), and primary Cesarean section (primary C-section, aOR1.49,95%CI1.09,2.03) in GDM women with HbA1c ≥5.5% while significantly associated with PIH (aOR 1.91,95%CI1.24,2.94) in women with HbA1c 5.1-5.4%. The associations between HbA1c and adverse outcomes varied with maternal age, pre-pregnancy BMI, and GWG. In women aged ≤29 years, there’s significant association between HbA1c and primary C-section when HbA1c was 5.1-5.4% and ≥5.5%. In women aged 29-34 years and HbA1c ≥5.5%, HbA1c was significantly associated with macrosomia. In women aged ≥35 years, there’s significant association between HbA1c and preterm birth when HbA1c was 5.1-5.4% and macrosomia and PIH when HbA1c ≥5.5%. In pre-pregnant normal-weight women, HbA1c was significantly associated with macrosomia, preterm birth, primary C-section, and PIH when HbA1c ≥5.5% while HbA1c was significantly associated with PIH when HbA1c was 5.1-5.4% . In pre-pregnant underweight women with HbA1c 5.1-5.4%, HbA1c was significantly associated with primary C-section. HbA1c was significantly associated with macrosomia among women with inadequate GWG or excess GWG and HbA1c≥5.5%. In women with adequate GWG, there’s significant association between HbA1c and PIH when HbA1c was 5.1-5.4% and ≥5.5% .

Conclusion: Conclusively, HbA1c at the time of diagnosis is significantly associated with macrosomia, preterm birth, PIH, and primary C-section in Chinese women with GDM.

4,850 views
10 citations

Objective: To develop the extreme gradient boosting (XG Boost) machine learning (ML) model for predicting gestational diabetes mellitus (GDM) compared with a model using the traditional logistic regression (LR) method.

Methods: A case–control study was carried out among pregnant women, who were assigned to either the training set (these women were recruited from August 2019 to November 2019) or the testing set (these women were recruited in August 2020). We applied the XG Boost ML model approach to identify the best set of predictors out of a set of 33 variables. The performance of the prediction model was determined by using the area under the receiver operating characteristic (ROC) curve (AUC) to assess discrimination, and the Hosmer–Lemeshow (HL) test and calibration plots to assess calibration. Decision curve analysis (DCA) was introduced to evaluate the clinical use of each of the models.

Results: A total of 735 and 190 pregnant women were included in the training and testing sets, respectively. The XG Boost ML model, which included 20 predictors, resulted in an AUC of 0.946 and yielded a predictive accuracy of 0.875, whereas the model using a traditional LR included four predictors and presented an AUC of 0.752 and yielded a predictive accuracy of 0.786. The HL test and calibration plots show that the two models have good calibration. DCA indicated that treating only those women whom the XG Boost ML model predicts are at risk of GDM confers a net benefit compared with treating all women or treating none.

Conclusions: The established model using XG Boost ML showed better predictive ability than the traditional LR model in terms of discrimination. The calibration performance of both models was good.

4,161 views
9 citations

Objective: This study aims to develop and evaluate a predictive nomogram for early assessment risk factors of gestational diabetes mellitus (GDM) during early pregnancy term, so as to help early clinical management and intervention.

Methods: A total of 824 pregnant women at Zhongnan Hospital of Wuhan University and Maternal and Child Health Hospital of Hubei Province from 1 February 2020 to 30 April 2020 were enrolled in a retrospective observational study and comprised the training dataset. Routine clinical and laboratory information was collected; we applied least absolute shrinkage and selection operator (LASSO) logistic regression and multivariate ROC risk analysis to determine significant predictors and establish the nomogram, and the early pregnancy files (gestational weeks 12–16, n = 392) at the same hospital were collected as a validation dataset. We evaluated the nomogram via the receiver operating characteristic (ROC) curve, C-index, calibration curve, and decision curve analysis (DCA).

Results: We conducted LASSO analysis and multivariate regression to establish a GDM nomogram during the early pregnancy term; the five selected risk predictors are as follows: age, blood urea nitrogen (BUN), fibrinogen-to-albumin ratio (FAR), blood urea nitrogen-to-creatinine ratio (BUN/Cr), and blood urea nitrogen-to-albumin ratio (BUN/ALB). The calibration curve and DCA present optimal predictive power. DCA demonstrates that the nomogram could be applied clinically.

Conclusion: An effective nomogram that predicts GDM should be established in order to help clinical management and intervention at the early gestational stage.

2,571 views
5 citations
Open for submission
Frontiers Logo

Frontiers in Endocrinology

Recent Advances in Gestational Diabetes: Diagnosis, Treatment and Prevention
Edited by John Punnose, Christian Göbl, Sarah Glastras, Andrea Tura
Deadline
11 April 2025
Submit a paper
Recommended Research Topics
Frontiers Logo

Frontiers in Endocrinology

Diabetes During and Beyond Pregnancy: A Life Course Perspective
Edited by Wei Bao, Margarita de Veciana
119.2K
views
120
authors
16
articles
Frontiers Logo

Frontiers in Endocrinology

Research Advances in Gestational Diabetes Mellitus, Neonatal Diabetes Mellitus, and Metabolic Disorders
Edited by Ihtisham Bukhari, Furhan Iqbal, Rick Francis Thorne
92.6K
views
164
authors
21
articles
Frontiers Logo

Frontiers in Endocrinology

Gestational Diabetes Mellitus and Long-term Maternal Outcomes
Edited by Marilza Rudge, RAGHAVENDRA L.S. HALLUR, Costanza Emanueli, Luis Sobrevia
63.2K
views
141
authors
19
articles
Frontiers Logo

Frontiers in Endocrinology

Research Advances in Gestational Diabetes Mellitus, Neonatal Diabetes Mellitus, and Metabolic Disorders Volume II
Edited by Ihtisham Bukhari, Rick Francis Thorne, Furhan Iqbal
30.4K
views
64
authors
8
articles
Frontiers Logo

Frontiers in Endocrinology

Management of Pregestational Diabetes in Pregnancy and Impact on Maternal, Fetal and Childhood Outcomes
Edited by Katrien Benhalima, Lene Ringholm, Anne VAMBERGUE, Aoife Egan
39.7K
views
43
authors
7
articles