The vascular endothelium has a central role in the regulation of blood flow through continuous modulation of vascular tone, where healthy endothelial cells are essential for maintenance of vascular homeostasis involving antioxidant, anti-inflammatory, pro-fibrinolytic, anti-adhesive, or anticoagulant effects. Oppositely, endothelial dysfunction is principally characterized by impaired endothelium - dependent transduction mechanisms related to vascular relaxation, as an outcome of decreased release of endothelium-derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium-derived contracting factors. Current data strongly suggest that endocrine pathological disorders, including impaired glucose tolerance, type 2 diabetes, metabolic syndrome, dyslipidemia, obesity, polycystic ovary syndrome, gestational diabetes, subclinical hypothyroidism, primary hyperparathyroidism, primary aldosteronism, Cushing's syndrome, hypopituitarism, or COVID-19 – related endocrine disorders include notable vascular changes associated with endothelial dysfunction.
The goal of this research topic is to summarize some of the latest clinical findings related to the role of endothelial dysfunction in aetiology and pathogenesis of different endocrine disorders, as well as existing and novel therapeutic possibilities for modulating and improving endothelial dysfunction in treatment of endocrine diseases. This is substantiated with still increasing data pointing out that pharmacological approach in improving or reversal of endothelial dysfunction was shown to be beneficial in clinical trials aimed to this scientific problem.
Specific themes:
- aetiology of endothelial dysfunction in endocrine disorders
- contribution of endothelial dysfunction in pathogenesis of endocrine disorders
- biomarkers of endothelial dysfunction in endocrine disorders
- non-invasive clinical protocols for detection of endothelial dysfunction in endocrine disorders
- endothelial dysfunction as a consequence of endocrine disorders
- COVID-19 and endothelial dysfunction interplay in endocrine disorders
- treatment options for improvement or reversal of endothelial dysfunction in endocrine disorders
- prevention possibilities against endothelial dysfunction occurrence in endocrine disorders
Type of papers:
- Original research papers
- Review papers
The vascular endothelium has a central role in the regulation of blood flow through continuous modulation of vascular tone, where healthy endothelial cells are essential for maintenance of vascular homeostasis involving antioxidant, anti-inflammatory, pro-fibrinolytic, anti-adhesive, or anticoagulant effects. Oppositely, endothelial dysfunction is principally characterized by impaired endothelium - dependent transduction mechanisms related to vascular relaxation, as an outcome of decreased release of endothelium-derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium-derived contracting factors. Current data strongly suggest that endocrine pathological disorders, including impaired glucose tolerance, type 2 diabetes, metabolic syndrome, dyslipidemia, obesity, polycystic ovary syndrome, gestational diabetes, subclinical hypothyroidism, primary hyperparathyroidism, primary aldosteronism, Cushing's syndrome, hypopituitarism, or COVID-19 – related endocrine disorders include notable vascular changes associated with endothelial dysfunction.
The goal of this research topic is to summarize some of the latest clinical findings related to the role of endothelial dysfunction in aetiology and pathogenesis of different endocrine disorders, as well as existing and novel therapeutic possibilities for modulating and improving endothelial dysfunction in treatment of endocrine diseases. This is substantiated with still increasing data pointing out that pharmacological approach in improving or reversal of endothelial dysfunction was shown to be beneficial in clinical trials aimed to this scientific problem.
Specific themes:
- aetiology of endothelial dysfunction in endocrine disorders
- contribution of endothelial dysfunction in pathogenesis of endocrine disorders
- biomarkers of endothelial dysfunction in endocrine disorders
- non-invasive clinical protocols for detection of endothelial dysfunction in endocrine disorders
- endothelial dysfunction as a consequence of endocrine disorders
- COVID-19 and endothelial dysfunction interplay in endocrine disorders
- treatment options for improvement or reversal of endothelial dysfunction in endocrine disorders
- prevention possibilities against endothelial dysfunction occurrence in endocrine disorders
Type of papers:
- Original research papers
- Review papers
