Antimicrobial and Anticancer Peptides

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Editorial

06 February 2018

Editorial: Antimicrobial and Anticancer Peptides

Neil M. O'Brien-Simpson

,

Ralf Hoffmann

,

C. S. Brian Chia

and

John D. Wade

5,107 views

21 citations

Editors

4

Neil Martin O'Brien-Simpson

The University of Melbourne

Florey Institute of Neuroscience and Mental Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne

Experimental Therapeutics Centre (A*STAR)

Leipzig University

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Peptides that are structurally amphipathic and predominately either anionic or cationic are often found to possess the ability to kill microbes and/or cancer cells. There are a large range of antimicrobial peptides (AMPs) that have been identified from a variety of organisms have been found to not only kill microbes but also kill cancer cells. Thus many AMPs are or potentially are anticancer peptides (ACPs). This Research Topic will bring together research investigating how AMPs and ACPs are being used, functionalised and produced for clinical applications through a collection of original research and reviews. A primary aim is to highlight approaches that are used to improve efficacy of AMPs and ACPs and also draw attention to similarities in approaches and also what approaches work in one area but not in another. It is hoped that this collection of work would provide researchers with a bank of knowledge to aid in the design of AMPs and ACPs to combat the worldwide problem of antibiotic resistance in microbes and in treating cancer and chemotherapeutic-resistant disease.

Peptides that are structurally amphipathic and predominately either anionic or cationic are often found to possess the ability to kill microbes and/or cancer cells. There are a large range of antimicrobial peptides (AMPs) that have been identified from a variety of organisms have been found to not only kill microbes but also kill cancer cells. Thus many AMPs are or potentially are anticancer peptides (ACPs). This Research Topic will bring together research investigating how AMPs and ACPs are being used, functionalised and produced for clinical applications through a collection of original research and reviews. A primary aim is to highlight approaches that are used to improve efficacy of AMPs and ACPs and also draw attention to similarities in approaches and also what approaches work in one area but not in another. It is hoped that this collection of work would provide researchers with a bank of knowledge to aid in the design of AMPs and ACPs to combat the worldwide problem of antibiotic resistance in microbes and in treating cancer and chemotherapeutic-resistant disease.

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Editors

Neil Martin O'Brien-Simpson

The University of Melbourne

Florey Institute of Neuroscience and Mental Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne

Experimental Therapeutics Centre (A*STAR)

Leipzig University

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111,685 Total views

83,472 Article views

24,732 Article downloads

3,481 Topic views

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Frontiers in Chemistry

Chemical Biology

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Frontiers in Molecular Biosciences

Chemical Biology

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