With the development of vaccinology, vaccine design tends to be more accurate and rational. Individual protein or polysaccharide antigens, or even smaller epitopes, are usually immunized as antigens. Although the safety of this subunit vaccine has been greatly improved, such products often face low immunogenicity. In order to solve this problem, more and more scientists focus on improving the specific immune response by coupling the antigen with an appropriate carrier. Among them, nanocarriers, which have the special lymph node drainage effect and immune activation ability, have attracted much attention in recent years. As reported, antigens coupling with nanocarriers could induce a high level of immune response even sometimes without the addition of adjuvants. Considering some conditions, such as shape, size, surface properties and method of coupling of the nanocarrier also affect the final immune effect. Therefore, the selection and design of nanocarriers are very important for immunization. At present, a variety of nanocarriers have been used for vaccines, such as toxin protein (e.g., Cholera Toxin Subunit B (CTB)), virus-like particle (VLP), outer membrane vesicle (OMV), self-assembled particle, liposome, emulsion, and polymeric particles. In addition, many new nano-scaled carriers have shown great potential in the development of both prophylactic and therapeutic vaccines. In conclusion, nanocarriers play an important role in the immune enhancement of weak antigens.
This Research Topic aims to obtain advanced multidisciplinary knowledge on recent advances in the designs, synthesis, and applications of nanocarriers for the vaccine. The published papers are expected to promote public understanding and shed light on the future direction of this field.
We welcome high-quality Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Synthesis of conjugate vaccines
• Design of novel nanocarriers for vaccines
• Design and synthesis of advanced self-assembled nanoparticles
• Coupling strategy of carrier and antigen
• Nano-scaled toxin protein and its adjuvant effect
• Advanced delivery system of vaccines
• Evaluation of immunogenicity enhancement of antigen by carriers
• Immune mechanism of nanovaccine
• Influence of different carrier properties on immune effect
With the development of vaccinology, vaccine design tends to be more accurate and rational. Individual protein or polysaccharide antigens, or even smaller epitopes, are usually immunized as antigens. Although the safety of this subunit vaccine has been greatly improved, such products often face low immunogenicity. In order to solve this problem, more and more scientists focus on improving the specific immune response by coupling the antigen with an appropriate carrier. Among them, nanocarriers, which have the special lymph node drainage effect and immune activation ability, have attracted much attention in recent years. As reported, antigens coupling with nanocarriers could induce a high level of immune response even sometimes without the addition of adjuvants. Considering some conditions, such as shape, size, surface properties and method of coupling of the nanocarrier also affect the final immune effect. Therefore, the selection and design of nanocarriers are very important for immunization. At present, a variety of nanocarriers have been used for vaccines, such as toxin protein (e.g., Cholera Toxin Subunit B (CTB)), virus-like particle (VLP), outer membrane vesicle (OMV), self-assembled particle, liposome, emulsion, and polymeric particles. In addition, many new nano-scaled carriers have shown great potential in the development of both prophylactic and therapeutic vaccines. In conclusion, nanocarriers play an important role in the immune enhancement of weak antigens.
This Research Topic aims to obtain advanced multidisciplinary knowledge on recent advances in the designs, synthesis, and applications of nanocarriers for the vaccine. The published papers are expected to promote public understanding and shed light on the future direction of this field.
We welcome high-quality Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
• Synthesis of conjugate vaccines
• Design of novel nanocarriers for vaccines
• Design and synthesis of advanced self-assembled nanoparticles
• Coupling strategy of carrier and antigen
• Nano-scaled toxin protein and its adjuvant effect
• Advanced delivery system of vaccines
• Evaluation of immunogenicity enhancement of antigen by carriers
• Immune mechanism of nanovaccine
• Influence of different carrier properties on immune effect