Recurrence and metastasis of malignancy is a multistep process that involves the escape of tumor cells from the primary location, systemic translocation in the body, and adaptation to the foreign microenvironment of distant sites. The spread of cancer cells is mediated by the interaction between tumor cells (seeds) and the microenvironment of the host organ (soil). Emerging evidence has revealed several stages of the invasion-metastasis cascade, including epithelial-mesenchymal transition, angiogenesis, and immune surveillance escape. Moreover, host organs could develop premetastatic niches and be more vulnerable to cancer cell colonization, adaptation and growth.
During the process of recurrence and metastasis, several aspects need to be illustrated, which include patient clinical characteristics, tumor pathology and molecular subtypes, predictive and prognostic biomarkers, metabolism reprogramming, immune microenvironment, etc. Understanding the sophisticated process of recurrence and metastasis can help us identify novel therapeutic targets and interventional strategies against solid tumors, including gynecological, gastrointestinal, and genitourinary malignancies.
This topic aims to find new patient characteristics, biomarkers, treatment targets and potential underlying mechanisms to explain recurrence and metastasis, as well as to explore novel strategies and treatment methods. We welcome contributions of Original Research, Special Topic Abstract, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory covering clinical, translational and basic research on novel molecular mechanisms and clinical strategies for solid tumor recurrence and metastasis. Topics of interest include, but are not limited to, the following aspects:
● Clinical characteristics, pathological classifications and subtypes of solid tumors, especially those associated with patient prognosis.
● Tumor interaction with its microenvironment, biomarker to predict immunotherapy.
● Genetic evolution in the process of recurrence and metastasis.
● Epigenetic and post-translational modifications in metastasis-regulated genes.
● Non-coding RNAs and transcriptional regulation of metastasis-regulated genes;
● Phenotypic plasticity and disrupted differentiation of cancer cells.
● Novel therapeutic targets and clinical strategies against recurrence and metastasis.
Recurrence and metastasis of malignancy is a multistep process that involves the escape of tumor cells from the primary location, systemic translocation in the body, and adaptation to the foreign microenvironment of distant sites. The spread of cancer cells is mediated by the interaction between tumor cells (seeds) and the microenvironment of the host organ (soil). Emerging evidence has revealed several stages of the invasion-metastasis cascade, including epithelial-mesenchymal transition, angiogenesis, and immune surveillance escape. Moreover, host organs could develop premetastatic niches and be more vulnerable to cancer cell colonization, adaptation and growth.
During the process of recurrence and metastasis, several aspects need to be illustrated, which include patient clinical characteristics, tumor pathology and molecular subtypes, predictive and prognostic biomarkers, metabolism reprogramming, immune microenvironment, etc. Understanding the sophisticated process of recurrence and metastasis can help us identify novel therapeutic targets and interventional strategies against solid tumors, including gynecological, gastrointestinal, and genitourinary malignancies.
This topic aims to find new patient characteristics, biomarkers, treatment targets and potential underlying mechanisms to explain recurrence and metastasis, as well as to explore novel strategies and treatment methods. We welcome contributions of Original Research, Special Topic Abstract, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory covering clinical, translational and basic research on novel molecular mechanisms and clinical strategies for solid tumor recurrence and metastasis. Topics of interest include, but are not limited to, the following aspects:
● Clinical characteristics, pathological classifications and subtypes of solid tumors, especially those associated with patient prognosis.
● Tumor interaction with its microenvironment, biomarker to predict immunotherapy.
● Genetic evolution in the process of recurrence and metastasis.
● Epigenetic and post-translational modifications in metastasis-regulated genes.
● Non-coding RNAs and transcriptional regulation of metastasis-regulated genes;
● Phenotypic plasticity and disrupted differentiation of cancer cells.
● Novel therapeutic targets and clinical strategies against recurrence and metastasis.