Diabetes is a metabolic syndrome that can lead to the development of diabetic kidney disease (DKD), which, in turn, is a major cause of chronic kidney disease (CKD) and end-stage renal disease. It is known that hyperglycemia - a characteristic condition of diabetes - is the initial factor that is associated with DKD, but other mechanisms may contribute to its progression, since diabetic patients are still at risk of developing DKD despite the glycemic control by which they are submitted.
The factors associated with DKD progression are still not well understood. Therefore, it is essential to investigate the mechanisms secondary to hyperglycemia that may contribute to the progression of DKD. With this Research Topic, we intend to contribute to the understanding of the pathogenesis of DKD and CKD in diabetes so that new therapeutic strategies can be investigated and improved.
Recent advances on the morphofunctional and molecular characterization of renal glomeruli and tubules in the diabetic context will be interesting to understand the pathogenesis of DRD. Research articles, reviews, and brief reports will be accepted to contribute to the objective of this Research Topic.
This topic was conceptualized by Drs. Mariana Charleaux and Larissa de Araújo
Diabetes is a metabolic syndrome that can lead to the development of diabetic kidney disease (DKD), which, in turn, is a major cause of chronic kidney disease (CKD) and end-stage renal disease. It is known that hyperglycemia - a characteristic condition of diabetes - is the initial factor that is associated with DKD, but other mechanisms may contribute to its progression, since diabetic patients are still at risk of developing DKD despite the glycemic control by which they are submitted.
The factors associated with DKD progression are still not well understood. Therefore, it is essential to investigate the mechanisms secondary to hyperglycemia that may contribute to the progression of DKD. With this Research Topic, we intend to contribute to the understanding of the pathogenesis of DKD and CKD in diabetes so that new therapeutic strategies can be investigated and improved.
Recent advances on the morphofunctional and molecular characterization of renal glomeruli and tubules in the diabetic context will be interesting to understand the pathogenesis of DRD. Research articles, reviews, and brief reports will be accepted to contribute to the objective of this Research Topic.
This topic was conceptualized by Drs. Mariana Charleaux and Larissa de Araújo
