Thrombosis associated with inflammation (thromboinflammation) occurs often in a broad range of human disorders. Thrombus formation is initiated with dysfunctional endothelium that impaired its antithrombotic and anti-inflammatory function leading to the propagation of coagulation dysregulation, platelet activation, leukocyte recruitment to the blood vessel.
Thromboinflammation appears in vascular disorders (as venous thromboembolism, thrombophlebitis, arterial thrombosis, atherosclerosis, stroke), in cancer and also during infection as in sepsis and COVID-19. The inflammation context is well recognized, in metabolic & inflammatory disease such as diabetes, obesity, arthritis and systemic lupus erythematosus.
Within this Research Topic, we aim to foster insights into recent advances in thromboinflammation in cardiovascular disorders and to encourage further basic & translational research to investigate this process in metabolic, cancer, inflammatory, infectious aspect linked to vascular disorders. Additionally, this series seeks to include articles that consider current and potential clinical therapeutic options to prevent or treat thromboinflammation. The Research Topic should include cells involved in thrombo-inflammation and their involvement in vascular disorders. Different aspects could be studied from metabolic to inflammation and sterile to septic states.
Thrombosis associated with inflammation (thromboinflammation) occurs often in a broad range of human disorders. Thrombus formation is initiated with dysfunctional endothelium that impaired its antithrombotic and anti-inflammatory function leading to the propagation of coagulation dysregulation, platelet activation, leukocyte recruitment to the blood vessel.
Thromboinflammation appears in vascular disorders (as venous thromboembolism, thrombophlebitis, arterial thrombosis, atherosclerosis, stroke), in cancer and also during infection as in sepsis and COVID-19. The inflammation context is well recognized, in metabolic & inflammatory disease such as diabetes, obesity, arthritis and systemic lupus erythematosus.
Within this Research Topic, we aim to foster insights into recent advances in thromboinflammation in cardiovascular disorders and to encourage further basic & translational research to investigate this process in metabolic, cancer, inflammatory, infectious aspect linked to vascular disorders. Additionally, this series seeks to include articles that consider current and potential clinical therapeutic options to prevent or treat thromboinflammation. The Research Topic should include cells involved in thrombo-inflammation and their involvement in vascular disorders. Different aspects could be studied from metabolic to inflammation and sterile to septic states.