Tooth Enamel : Frontiers in Mineral Chemistry and Biochemistry, Integrative Cell Biology and Genetics

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Editorial

28 August 2018

Editorial: Tooth Enamel: Frontiers in Mineral Chemistry and Biochemistry, Integrative Cell Biology and Genetics

Steven J. Brookes

,

Ariane Berdal

,

Alexandre R. Vieira

,

Sylvie Babajko

and

Jennifer Kirkham

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Editors

4

Ariane Berdal

INSERM U1138 Centre de Recherche des Cordeliers (CRC)

Sylvie Babajko

INSERM U1138 Centre de Recherche des Cordeliers (CRC)

Steven Joseph Brookes

School of Dentistry, Faculty of Medicine and Health, University of Leeds

Alexandre Rezende Vieira

University of Pittsburgh

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The Topic will host an overview of the most recent knowledge on enamel issued from the panel of international experts involved in Tooth Enamel IX meeting. Presentations of original data, key notes and opinions will be welcomed. The Topic will also host Tooth Enamel IX discussions and debates, highlighting changing paradigms, pointing out unsolved and challenge questions and profiling scientific issues and translational prospects. Enamel topic will be by nature transdisciplinary, at the frontiers between integrative cell biology, biochemistry and mineral chemistry. Scientific reports on this unique mineral architecture and the sequential molecular interactions leading extracellular self-assembly will associate physics, chemistry, biochemistry and original modelizations. This knowledge will open a window on innovative biomimetics of interest in regenerative medicine. Molecular networks leading amelogenesis will exploit vertebrate enamel biodiversity as a landmark to draw the evolution of genes important in morphogenesis and mineralization and encoding transcription factors, growth factors, matrix proteins or enzymes. Tissue-specific networks and pathways shared with a number of biological systems (clock genes, epithelial polarization/ion handling, cell niche dynamics, cell signaling,…) will be explored. This will give an overall picture of the multiple acellular, cellular and animal (essentially transgenic mice) models handled in the enamel field. In the same line of thoughts, lessons from isolated or syndromic, inherited and acquired enamel defects will gather enamel phenotypes, cell and matrix-omics and outline the emerging genomic frame of enamel quality. Indeed tooth enamel defects fingerprint historical and present gene-environment modifications in animal and human condition such as climate, nutrition, pollutants or fluoride exposures. This last fact is highly relevant in medicine and public health since poor tooth quality and mineral defects are one of the first human worldwide pathologies.

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Editors

Ariane Berdal

INSERM U1138 Centre de Recherche des Cordeliers (CRC)

Sylvie Babajko

INSERM U1138 Centre de Recherche des Cordeliers (CRC)

Steven Joseph Brookes

School of Dentistry, Faculty of Medicine and Health, University of Leeds

Alexandre Rezende Vieira

University of Pittsburgh

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199,131 Total views

153,584 Article views

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4,226 Topic views

Published In

Frontiers in Physiology

Craniofacial Biology and Dental Research

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