The human microbiome is composed of bacteria, fungi, archaea and viruses that reside in and on our bodies. As we discover more about our microbiome, we gain fascinating insights into how intricately entwined our health is with that of these multi-kingdom microbes. Except for bacterial components, mycobiome (fungal microbiome) is gaining increasing attention most recently. Not only do they play a role in the fermentation of food and nutrition, but evidence now shows that the fungal commensals and their metabolites can, directly and indirectly, impact our health and the etiology of human disease. This knowledge will help us to identify new disease pathways and potential treatments based on the mycobiome.
Currently, our understanding of the human mycobiome remains in its infancy stage. The rapid development of sequencing, culturing and microbial handling technologies or approaches prompt us to decipher the mechanistic insights of mycobiome and human diseases such as cancer and so on. Thus, exploring the microenvironment and the mechanisms by which mycobiome and host cells interact might provide insights into how mycobiome responds to host immune defense signaling and successfully colonizes the human body which will reveal novel therapeutic targets and strategies to fight against diseases.
This research topic aims to 1) Increase the general attention to the relationship between mycobiome and human health; 2) Identify novel fungal species and/or fungal-derived bio-products that play essential roles in human diseases; 3) Promote the development of new technologies (including but not limited to high throughput multi-omic technologies like amplicon sequencing, meta-genomic, meta-transcriptomic, meta-proteomic, metabolomic, etc.) in studying mycobiome; 4) Uncover molecular mechanisms of host-fungal interaction in the aspect of mycobiome by the integration of in vitro and/or in vivo models; 5) Preclinical or clinical analyses identifying intrinsic and/or intrinsic factors that contribute to human health/disease through the regulation of mycobiome.
In this Research Topic, we welcome contributors to address diverse aspects of mycobiome and its role in the development and progression of human diseases in the form of original research and reviews. Potential topics include but are not limited to the following:
? Mechanism of host-fungal interactions in the aspect of mycobiome.
? Intrinsic and external factors associated with the inter-individual variation of mycobiome and the potential correlation with human diseases.
? Multi-kingdom microbial interaction in modulating mycobiome and host.
? Novel insights into triple interactions of “Nutrition-mycobiome-host”.
? Effects of drug intakes on the composition and/or biological activities of mycobiome.
? Novel technologies in the investigation of mycobiome.
? Mycobiome and fungal pathogenesis;
? Mycobiome and antifungal resistance and development;
? Mycobiome as diagnostic or therapeutic targets for human diseases.
The human microbiome is composed of bacteria, fungi, archaea and viruses that reside in and on our bodies. As we discover more about our microbiome, we gain fascinating insights into how intricately entwined our health is with that of these multi-kingdom microbes. Except for bacterial components, mycobiome (fungal microbiome) is gaining increasing attention most recently. Not only do they play a role in the fermentation of food and nutrition, but evidence now shows that the fungal commensals and their metabolites can, directly and indirectly, impact our health and the etiology of human disease. This knowledge will help us to identify new disease pathways and potential treatments based on the mycobiome.
Currently, our understanding of the human mycobiome remains in its infancy stage. The rapid development of sequencing, culturing and microbial handling technologies or approaches prompt us to decipher the mechanistic insights of mycobiome and human diseases such as cancer and so on. Thus, exploring the microenvironment and the mechanisms by which mycobiome and host cells interact might provide insights into how mycobiome responds to host immune defense signaling and successfully colonizes the human body which will reveal novel therapeutic targets and strategies to fight against diseases.
This research topic aims to 1) Increase the general attention to the relationship between mycobiome and human health; 2) Identify novel fungal species and/or fungal-derived bio-products that play essential roles in human diseases; 3) Promote the development of new technologies (including but not limited to high throughput multi-omic technologies like amplicon sequencing, meta-genomic, meta-transcriptomic, meta-proteomic, metabolomic, etc.) in studying mycobiome; 4) Uncover molecular mechanisms of host-fungal interaction in the aspect of mycobiome by the integration of in vitro and/or in vivo models; 5) Preclinical or clinical analyses identifying intrinsic and/or intrinsic factors that contribute to human health/disease through the regulation of mycobiome.
In this Research Topic, we welcome contributors to address diverse aspects of mycobiome and its role in the development and progression of human diseases in the form of original research and reviews. Potential topics include but are not limited to the following:
? Mechanism of host-fungal interactions in the aspect of mycobiome.
? Intrinsic and external factors associated with the inter-individual variation of mycobiome and the potential correlation with human diseases.
? Multi-kingdom microbial interaction in modulating mycobiome and host.
? Novel insights into triple interactions of “Nutrition-mycobiome-host”.
? Effects of drug intakes on the composition and/or biological activities of mycobiome.
? Novel technologies in the investigation of mycobiome.
? Mycobiome and fungal pathogenesis;
? Mycobiome and antifungal resistance and development;
? Mycobiome as diagnostic or therapeutic targets for human diseases.