Mechanistic regulation of nutrients metabolism including amino acids, glucose, and lipids is critical for cell survival and growth under various stress conditions. Multiple signaling pathways, such as Ras signaling, AMPK signaling, mTORC1/2 signaling and AKT signaling, have been elucidated to play important roles in reprograming cellular metabolism. For example, tumor cells are prone to rewiring their metabolic signaling pathways possibly due to the heterogeneity in response to environmental stimuli. Dysregulated expression of essential molecules involved in metabolic regulation and signaling transduction also gives us opportunities to decipher the detailed underlying mechanisms which could be utilized in the therapeutic translation into anti-cancer treatment. Besides, imbalance of cellular metabolic regulation eventually causes deficiency in the synthesis of particular metabolites or huge demands on certain nutrients (nutrient dependency), which could be considered as the metabolic Achilles’ heel of these cells and exposes metabolic vulnerabilities through targeting key regulatory molecules. Nutrient deprivation induces metabolic stresses, including energy stress, ER stress, and oxidative stress, which ultimately cause cell death or regulated cell death. Several types of regulated cell death such as apoptosis, necroptoisis and ferroptosis are implicated in multiple diseases, like tumor suppression, tissue or organ damage, and neurodegenerative disorders. Thus, perturbation of these regulated cell deaths provides us opportunities to ameliorate relevant diseases involving such types of cell death.
In this research topic, we aim to collect original research and review articles focusing on the mechanistic study of nutrient metabolism involving master regulators established a while ago as well as novel emerging players identified in recent studies. Besides, studies covering regulated cell death and like apoptosis, necroptosis, ferroptosis, ER-stress related cell death and autophagic cell death, are encouraged to submit. We also welcome manuscripts employing computational analyses combined with experimental validation to propose new biomarkers and druggable targets for diseases. We hope this research topic will give us more insights into the mechanistic regulation of cell metabolism and propose promising therapeutic strategies or druggable targets for various diseases.
Themes of interest include, but are not limited to the following aspects:
• Nutrients metabolism in cancer cells, including amino acids, glucose, lipids, etc.;
• Control of signaling transduction in the metabolic regulation;
• Study cellular metabolism under stress conditions, such as nutrient deprivation, energy stress, oxidative stress, hypoxia, etc.;
• Biomarkers and/or targets involved in metabolism in diseases;
• Mechanistic regulation of essential molecules in regulated cell death, at the epigenetic, transcriptional, translational or post-translational levels;
• Targeting metabolic vulnerabilities or intervening regulated cell death through pharmacological molecules in the treatment of diseases including cancer, organ damage and neurodegenerative disorders.
Mechanistic regulation of nutrients metabolism including amino acids, glucose, and lipids is critical for cell survival and growth under various stress conditions. Multiple signaling pathways, such as Ras signaling, AMPK signaling, mTORC1/2 signaling and AKT signaling, have been elucidated to play important roles in reprograming cellular metabolism. For example, tumor cells are prone to rewiring their metabolic signaling pathways possibly due to the heterogeneity in response to environmental stimuli. Dysregulated expression of essential molecules involved in metabolic regulation and signaling transduction also gives us opportunities to decipher the detailed underlying mechanisms which could be utilized in the therapeutic translation into anti-cancer treatment. Besides, imbalance of cellular metabolic regulation eventually causes deficiency in the synthesis of particular metabolites or huge demands on certain nutrients (nutrient dependency), which could be considered as the metabolic Achilles’ heel of these cells and exposes metabolic vulnerabilities through targeting key regulatory molecules. Nutrient deprivation induces metabolic stresses, including energy stress, ER stress, and oxidative stress, which ultimately cause cell death or regulated cell death. Several types of regulated cell death such as apoptosis, necroptoisis and ferroptosis are implicated in multiple diseases, like tumor suppression, tissue or organ damage, and neurodegenerative disorders. Thus, perturbation of these regulated cell deaths provides us opportunities to ameliorate relevant diseases involving such types of cell death.
In this research topic, we aim to collect original research and review articles focusing on the mechanistic study of nutrient metabolism involving master regulators established a while ago as well as novel emerging players identified in recent studies. Besides, studies covering regulated cell death and like apoptosis, necroptosis, ferroptosis, ER-stress related cell death and autophagic cell death, are encouraged to submit. We also welcome manuscripts employing computational analyses combined with experimental validation to propose new biomarkers and druggable targets for diseases. We hope this research topic will give us more insights into the mechanistic regulation of cell metabolism and propose promising therapeutic strategies or druggable targets for various diseases.
Themes of interest include, but are not limited to the following aspects:
• Nutrients metabolism in cancer cells, including amino acids, glucose, lipids, etc.;
• Control of signaling transduction in the metabolic regulation;
• Study cellular metabolism under stress conditions, such as nutrient deprivation, energy stress, oxidative stress, hypoxia, etc.;
• Biomarkers and/or targets involved in metabolism in diseases;
• Mechanistic regulation of essential molecules in regulated cell death, at the epigenetic, transcriptional, translational or post-translational levels;
• Targeting metabolic vulnerabilities or intervening regulated cell death through pharmacological molecules in the treatment of diseases including cancer, organ damage and neurodegenerative disorders.